Constituents and Antimicrobial Activity of Oil from Withania somnifera Grown in Sudan
Keywords:
Withania Somnifera, Oil, GC- MS, Antimicrobial Activity
Abstract
This study was schematized to identify and quantify the constituents of Sudanese Withania somnifera oil and to evaluate the antimicrobial activity of the extracted oil. GC- MS analysis of the oil revealed the presence of: 9, 12-octadecadienoic acid (Z, Z)-, methyl ester (60.47 %); 9-octadecenoic acid (Z)-, methyl ester (16.02 %); hexadecanoic acid, methyl ester (14.46 %), beside other minor constituents. In cup plate agar diffusion assay, the oil was screened for antimicrobial activity against five standard human pathogens. Withania somnifera oil exhibited moderate activity against Escherichia coli and Bacillus subtilis.
References
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Chandra S, Chatterjee P, Dey P, Bhattacharya S (2012) Evaluation of anti-inflammatory effect of Ashwagandha: a preliminary study in vitro. Phcog J., 4:47–49
Gauttam VK, Kalia AN , Development of polyherbal antidiabetic formulation encapsulated in the phospholipids vesicle system. J Adv Pharm Technol Res., 2013, 4:108–117.
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Kour K, Pandey A, Suri KA, Satti NK, Gupta KK, Bani S .(2009),Restoration of stress-induced altered T cell function and corresponding cytokines patterns by Withanolide A. Int Immunopharmacol, 9:1137–1144.
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Mirjalili MH, Fakhr-Tabatabaei SM, Alizadeh H, Ghassempour A, Mirzajani F., Geneticand Withaferin A analysis of Iranian natural populations of Withania somnifera and W. coagulans by RAPD and HPTLC. Nat Prod Commun , 2009,4:337–346.
Mishra B (2004) Ashwagandha – Bhavprakash Nigantu (Indian Materia Medica). Chaukhambha Bharti Academy, Varanasi, pp 393–394
Mishra L-C, Singh BB, Dagenais S(2000)., Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Altern Med Rev., 5:334–346
Singh D, Aggarwal A, Maurya R, Naik S.(2007) , Withania somnifera Inhibits NF-κB and AP-1 transcription factors in human peripheral blood and synovial fluid mononuclear cells. Phytother Res, 21:905–913
Singh N, Bhalla M, de Jager P, Gilca M. , An overview on ashwagandha: a Rasayana (rejuvenator) of Ayurveda. Afr J Tradit Complement Altern Med.,2011, 8:208–213.
Singh N, Singh S, Nath C, Kohli R, Bhargava K (1984) Anti-stress plants as anti-rheumatic agents. 5th sepal congress of rheumatology, Bangkok.
Winters M (2006) Ancient medicine, modern use: Withania somnifera and its potential role in integrative oncology. Altern Med Rev 11:269–277.
Bhandari C (1970) Ashwagandha (Withania somnifera)“Vanaushadhi Chandroday”(An Encyclopedia of Indian Herbs), vol 1. CS Series of Varanasi Vidyavilas Press, Varanasi, pp 96–97
Chandra S, Chatterjee P, Dey P, Bhattacharya S (2012) Evaluation of anti-inflammatory effect of Ashwagandha: a preliminary study in vitro. Phcog J., 4:47–49
Gauttam VK, Kalia AN , Development of polyherbal antidiabetic formulation encapsulated in the phospholipids vesicle system. J Adv Pharm Technol Res., 2013, 4:108–117.
Govardhan S (1938) Ashwagandharishta – Rastantra Sar Evam Sidhyaprayog Sangrah. Krishna– Gopal Ayurveda Bhawan (Dharmarth Trust), Nagpur, pp 743–744.
Kour K, Pandey A, Suri KA, Satti NK, Gupta KK, Bani S .(2009),Restoration of stress-induced altered T cell function and corresponding cytokines patterns by Withanolide A. Int Immunopharmacol, 9:1137–1144.
Kulkarni SK, Dhir A., Withania somnifera: an Indian ginseng. Prog Neuro-Psychopharmacol Biol Psychiatry,2008, 32:1093–1105
Kuttan G.(1996) , Use of Withania somnifera Dunal as an adjuvant during radiation therapy. Indian J Exp Biol., 34:854–856.
Mirjalili MH, Fakhr-Tabatabaei SM, Alizadeh H, Ghassempour A, Mirzajani F., Geneticand Withaferin A analysis of Iranian natural populations of Withania somnifera and W. coagulans by RAPD and HPTLC. Nat Prod Commun , 2009,4:337–346.
Mishra B (2004) Ashwagandha – Bhavprakash Nigantu (Indian Materia Medica). Chaukhambha Bharti Academy, Varanasi, pp 393–394
Mishra L-C, Singh BB, Dagenais S(2000)., Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Altern Med Rev., 5:334–346
Singh D, Aggarwal A, Maurya R, Naik S.(2007) , Withania somnifera Inhibits NF-κB and AP-1 transcription factors in human peripheral blood and synovial fluid mononuclear cells. Phytother Res, 21:905–913
Singh N, Bhalla M, de Jager P, Gilca M. , An overview on ashwagandha: a Rasayana (rejuvenator) of Ayurveda. Afr J Tradit Complement Altern Med.,2011, 8:208–213.
Singh N, Singh S, Nath C, Kohli R, Bhargava K (1984) Anti-stress plants as anti-rheumatic agents. 5th sepal congress of rheumatology, Bangkok.
Winters M (2006) Ancient medicine, modern use: Withania somnifera and its potential role in integrative oncology. Altern Med Rev 11:269–277.
Published
2022-12-29
Section
Articles
