Haematological Effects of Aqueous Extracts of Geigeria alata in Male Albino Rats
Abstract
The indigenous medicinal plants in Sudan form an important component of the natural wealth of the country. The effects of oral administration of Geigeria alata aqueous extract at doses 500, 1000, and 1500 mg/kg body weight on haematological profiles in male albino rats was investigated in this research work. Albino rat animals were divided into four groups of 6 animals each. Group1: control, Group 2, 3 and 4 were administrated orally by 500, 1000 and 1500 mg/kg body weight, plant extracts respectively, throughout the experiment which contained for consecutive 14 days. The blood parameters measured were: haemoglobin (Hb), Packed Cell Volume (PCV), Red Blood Cells (RBC), White Blood Cells (WBC), Mean Corpuscular Volume (MCV), Mean Corpuscular Haemoglobin Concentration (MCHC), Lymphocytes and Neutrophils, Lymphocytes and Neutrophils, plant extract after 14 days did not produce any significant change (P < 0.05) on haemotological parameters tested, relative to their respective control. Significant changes were noted in body weights of rats treated with 1500 mg/kg body weight after 14 days, relative to Control Group. Sub-acute toxicity studies in rats showed that no mortality was recorded in any of the groups even at 1500 mg/kg body weight dose.
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