Long-range proton–carbon coupling constants for the determination of the stereochemical structure of organic compounds.

  • Anwar, E. M. Noreljaleel
Keywords: HSQC-TOCSY, J-coupling, 2D NMR

Abstract

A new methods for elucidating stereochemistry of organic compounds was developed on the basis of long-range proton–carbon coupling constants (2,3JC,H) and interpreting spin-coupling constants (3JH,H). Reaction of compound containing pyrin ring with nucleophile reagent was done to open the ring. HSQC-TOCSY experiments one of the new NMR spectroscopy method used to measure this values of spin-coupling constants and elucidating the stereochemistry of the product.

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Published
2021-08-17