Elevation of Gonadotropin Hormones as Early Predictor Marker for Subfertility among Sudanese Patient with Chronic Kidney Disease Stage-5
Background: Chronic kidney disease (CKD) is defined as the decrease of glomerular filtration rate (GFR) that leads to a progressive deterioration of fluid-electrolyte balance and metabolic or endocrinological functions. Furthermore, the relation of CKD with infertility and sexual dysfunction is well-known to affect medical health status as well as physiological status. Additionally, in men with CKD, gonadal dysfunction with elevation of serum gonadotropin concentration is a frequent finding, affecting 26% – 66 % of men with different stages of CKD. The objective of this study is to investigate the serum gonadotropins LH and FSH in patients with CKD.
Methods: This case-control study was conducted at military hospital, police hospital and Kidney transplantation association within six months from November 2017 to April 2018. More importantly, the study was carried out on a total of 80 samples including 40 CKD patients as case and 40 healthy individuals as control group. Finally, serum FSH and LH levels were estimated using ELISA technique and data was analyzed using SPSS software program version 21.
Results: This study has found significant elevation in FSH and LH levels with p-value (0.000, 0.001) respectively in CKD patients compared to control group. Moreover, the study found that FSH level is positively correlated with BMI and duration of disease, while LH level is positively correlated with the duration of disease only.
Conclusion: Our study concluded that patients with CKD have elevated gonadotropins (FSH&LH) levels.
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