Human T-lymphotropic Virus Type 1/2 In Renal Transplant Recipients and Hemodialysis Patients in Khartoum state
Background: The human T-lymphotropic virus or human T-cell leukemia-lymphoma virus (HTLV) is one of human retroviruses family. There are numerous sorts of HTLV; The human T lymphocyte virus 1 (HTLV-1) is a kind of HTLV that can be a reason for some maladies, for example, HTLV-1 related myelopathy (HAM) and adult T-cell leukemia, (ATL). HTLV-2 is another kin-d of HTLV however it isn't care for HTLV-1 it is less pathogenesis. Patients with hemodialysis powerless to viral contamination since some infections like HTLV can be transmitted by blood; additionally patients with renal transplantation are defenseless to viral diseases because of their immune compromised background.
Objective: This study aims to provide data about prevalence of (HTLV1/2) among renal transplant recipients and hemodialysis in Khartoum State.
Materials and methods: A total of 100 patients, 50 patients had renal transplantation and the other 50 patients on hemodialysis. Blood samples were obtained to measure HTLV type 1/2 antibodies using Enzyme-linked Immuno Sorbent Assay (ELISA). The study was done in the period from June to November 2017 in Khartoum state. And SPSS 20 software and Microsoft Excel were used for the statistical analysis.
Results: The study showed among hemodialysis patients, 2 out of 50 (4%) were seropositive for HTLV1\2, IgG antibodies and 48 (96%) of the cases were sero-negative. Also showed among renal transplant recipients all of them were sero-negative for HTLV1\2 IgG antibodies. The percentage of male and female in the hemodialysis patients was 62.0 % and 38.0 % respectively and in renal transplantation patients was 76.0 % and 24.0 % respectively.
Conclusion: The human T-lymphotropic virus 1/2 seropositive was found among hemodialysis patients, and the HTLV1/2 sero-negative was found in renal transplant recipients in Khartoum, Sudan. Thus the prevalence of HTLV 1/2 in a large sample size in Sudan should be conducted.
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