Frequency of Euthyroidism among Patients with Goiter in Algeneina Town, West Darfur State

  • Alsafat Mohammed Ibrahim
Keywords: Euthyriosism. Euthyroid, goitrous, goiter, TSH, hyperthyroidism

Abstract

This is a cross sectional hospital-based study carried out to measure the levels of thyroid hormones (T3, T4 and TSH) in Sudanese patients with goiter in west Darfur state (Algeniena City) during the period from April to July 2011.

 Eighty Sudanese patients with goiter; including 20 males (aged 10-65years), and 70 females (aged 10-65years), were enrolled in this study; also 40 healthy individuals to serve as control group; including 20 males (aged 10-65 years), and 20 females (aged 10-65 years).

Five ml of venous blood were collected from each participant to obtain serum. T3, T4 and TSH levels were measured by Enzyme linked immuno assay (ELISA) technique.

Statistical analysis revealed that 64 samples (82.5%) were found to have normal thyroid hormones levels (euthyroid), while 6 samples (7.5%) were found to have hyperthyroidism, 4 samples (5.0%) were found to have hypothyroidism, and four samples (5.0%) had high TSH and normal T3 and T4 .

Results showed that T4 and TSH were significantly decreased in patients with goiter compared with control group, (p value 0.00) and (p value 0.01) respectively. Unlike T3 since no difference was found between patients and the healthy control group (p value 0.76).

This study concluded that the frequency of goiter was high among people in west Darfur state (Algeneina city) with higher percentage in females than males. Also, the frequency of goitrous euothyroidism was higher compared to both, goitrous hyperthyroidism and goitrous hypothyroidism.

References

- Baynes JW, Dominiczak MH. Medical Biochemistry. 2nd ed. Mosby; (2005). p. 319-325.
- Burtis CA, Ashwood ER, Bruns DE, Sawyer BG. Thyroid gland Function and Disease. TIETS Fundamentals of Clinical Chemistry. 6th ed. Philadelphia: Saunders, ElsevierInc; (2008). p. 632-653.
- Chopra IJ, Hershman JM, Hornabrook RW. Serum thyroid hormone and thyrotropin levels in subjects from endemic goiter regions of New Guinea. J Clin Endocrinol Metab. (1975 Feb); 40(2):p. 326-33.
- Eltom,M., Hovander,I., and fell storm, B., Endemic goiter in Darfur region Sudan Acta Med. Scand. (1984). 215, p. 467-475.
- Fox SI. Physiology of the Thyroid gland . Human Physiology. 9th ed. NewYork: McGraw-Hill Companies. Inc; (2006). p. 575
- Mayne P.D. chnicaln chemistry m Diagnosis and Treatment . 6th ed. , London , Edward Amold, 224 14-Micallef , J ; Ahsan , R (1994) Immunoassay :Laboratory of immunoassay.Edited by J.P. Gosling
and L.V Basso,Butter worth.Heuimann.
- Myers AR. Clinical Medicine, 4th ed. Lippincott Wilkins; (2001). p. 309-379.
- Peter L, Susanne B. Iodine intake and prevention of thyroid disorder; (2002), p.45-46.
- Rallison ML, Dobyns BM, Meikle AW, Bishop M, Lyon JL & Stevens W. Natural history of thyroid abnormalities: prevalence, incidence and regression of thyroid
diseases in adolescents and young adults. Am J Med 1991; 91(4):p.363-70.
Published
2019-12-31