Frequency of Euthyroidism among Patients with Goiter in Algeneina Town, West Darfur State
This is a cross sectional hospital-based study carried out to measure the levels of thyroid hormones (T3, T4 and TSH) in Sudanese patients with goiter in west Darfur state (Algeniena City) during the period from April to July 2011.
Eighty Sudanese patients with goiter; including 20 males (aged 10-65years), and 70 females (aged 10-65years), were enrolled in this study; also 40 healthy individuals to serve as control group; including 20 males (aged 10-65 years), and 20 females (aged 10-65 years).
Five ml of venous blood were collected from each participant to obtain serum. T3, T4 and TSH levels were measured by Enzyme linked immuno assay (ELISA) technique.
Statistical analysis revealed that 64 samples (82.5%) were found to have normal thyroid hormones levels (euthyroid), while 6 samples (7.5%) were found to have hyperthyroidism, 4 samples (5.0%) were found to have hypothyroidism, and four samples (5.0%) had high TSH and normal T3 and T4 .
Results showed that T4 and TSH were significantly decreased in patients with goiter compared with control group, (p value 0.00) and (p value 0.01) respectively. Unlike T3 since no difference was found between patients and the healthy control group (p value 0.76).
This study concluded that the frequency of goiter was high among people in west Darfur state (Algeneina city) with higher percentage in females than males. Also, the frequency of goitrous euothyroidism was higher compared to both, goitrous hyperthyroidism and goitrous hypothyroidism.
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