Frequency of Gestational diabetes mellitus and impaired glucose tolerance in urban Sudanese pregnant women in the third trimester
الملخص
Background: Impaired glucose tolerance may be defined as intermediate group of individuals
whose carbohydrate metabolism does not constitute diabetes but is not entirely normal. It carries a
higher risk of developing microvascular disease and a significant percentage of these patients
eventually become diabetics.
Objective: of the study was to estimate the frequency of gestational diabetes mellitus (GDM) and
impaired glucose tolerance (IGT) in urban Sudanese pregnant women in the third trimester. The
study also showed the effect of age and parity on IGT.
Methodology: The study was carried out on hundred pregnant women in the third trimester.
Results: The frequency of gestational diabetes was 2% and it was 6% for the IGT incidence
whereas, 92% of the pregnant women revealed normal fasting plasma levels.
The IGT pregnant women were older than the control pregnant women but, the age difference was
not significant [28.7± 5.5 years (mean ± S.D) vs. 27.3 ± 4.8 respectively, p>0.05] .
Also, the IGT pregnant women were found to have mean parity significantly greater than that of the
control group [ 6.7 ± 2 (mean ± S.D.) vs. 3.9 ± 2.1 respectively , p<0.001].
Conclusion: The frequency of GDM and IGT in Sudanese pregnant women is within the universal
estimates and parity is an important risk factor that affects impaired glucose tolerance incidence in
pregnancy.
المراجع
2. Brudnell M. (1993) Diabetic Pregnancy. In:Turnbull S.A., Chamberlain G. (eds) Obstetrics.Second edition. Churchill Livingstone, Edinburgh,London, Melbourne and Newyork. Ch.39 pp.585-602.
3. Hope R.A., Longmore J.M., Hodgetts T.J. &Ramrakha P.S. (1993) Oxford handbook of clinicalmedicine. 3rd edition, Oxford University Press, pp.528-529.
4. Sepe S J, Connel FA, Geiss LS et al. Gestationaldiabetes – incidence, maternal characteristics andperinatal outcome. Diabetes 1985;34(suppl.2): 13-16.
5. Summary and recommendations of the secondinternational workshop conference of gestationaldiabetes. Diabetes 1985;34 (suppl.2): 123-126.
6. Stock S, Bremme K and Uvans-Moberg K. Isoxytocin involved in the deterioration of glucosetolerance in gestational diabetes? Gynaecol.Obstet. Invest1993; 36: 81-86.
7. Damm P, Kuhl C, Buchard K et al. Prevalenceand predictive value of islet cell antibodies andinsulin autoantibodies in women with gestationaldiabetes. Diabetic Medicine 1994;11:558-563.
8. Chamberlain G. (1995) Obstetrics (By TenTeachers) 16th edition. Arnold. London, Boston,Sydney and Auckland. pp.24-26 and pp.122-124.
9. Alshawaf T, Akiel A and Moghraby SAA.Gestational diabetes and impaired glucosetolerance of pregnancy in Riadh. British Journal ofObstetrics and Gynaecology. 1986;95(1): 84-90.
10. Kuhl C, Hornnes PJ and Andersen O. Etiology andpathophysiology of gestational diabetes mellitus.Diabetes 1985;34 (suppl. 2):66-70.
11. MacFarlane A, Wright AD, Evans SE et al.Impaired glucose tolerance in the third trimester ofpregnancy. Diabetic Medicine 1985; 2: 260-261.
12. Nasrat AA, Augensen K, Abushal et al. Theoutcome of pregnancy following untreatedimpaired glucose tolerance. Int. J. Gynaecol.Obstet1994;47(1): 1- 6.
13. Kuhl C. Aetiology of gestational diabetes.Bailliere's Clinical Obstetric and Gynaecology1991;5(2): 279-292.
14. Peters R, Kjos S, Xiang A. and Buchanan T. Effectof a second pregnancy on the risk of non-insulindependentdiabetes in women with recentgestational diabetes. Diabetes. 1995;Abstract book44 (suppl. 1): 14A (Abstract no. 45).