The Insects Antimicrobial Peptides' Properties, Importance and Mode of Action
Keywords:
Insect antimicrobial peptides, Innate immunity, AMP applications, Mode of action
Abstract
Anti-microbial peptides Antimicrobial peptides (AMP) are widely recognized as promising alternatives to the current use of antibiotics and fungicides. There are many desirable features, such as low cost of production, rapidity, heat-tolerant, relatively broad antimicrobial spectrum and low toxicity to eukaryotic cells made of antimicrobial peptides to be a new alternative to the conventional antibiotic. Wildly distributed in insects, plants and animal, native antibiotic peptides have anti-fungal, anti-bacterial, anti-virus, anti-parasitic and anti-cancer effects. AMPs from insect are classically cationic and usually composed of less than one hundred amino acids. While their structures are diverse, the majority of the AMPs can be classified into a limited number of families. The most frequent structures are represented by peptides presuming the alpha-helical structure in organic solutions or disulfide-stabilized β-sheets with or without α-helical domains present. Despite an affluence of information on structural requirements for their antipathogens activity, the mode of action of these peptides is not yet completely understood, therefore an understanding of Insect AMPs mechanism of action on pathogens will develop their uses as therapeutics means. Here we aim to have a comprehensive review of the research work reveal the mode of action of antimicrobial peptides from insects as well as shed the light on their therapeutic applications.
References
Ando, K.; Natori, S. Inhibitory effect of sarcotoxin IIA, an antibacterial protein of Sarcophaga peregrina, on growth of Escherichia coli. J. Biochem.1988, 103, 735-739.
Baghian, A.; Jaynes, J.; Enright, F.; Kousoulas, K. G. An amphipathic alpha-helical synthetic peptide analogue of melittin inhibits herpes simplex virus-1 (HSV-1)-induced cell fusion and virus spread. Peptides.1997, 18, 177-183.
Bobek, L. A.; Situ, H. MUC7 20-Mer: investigation of antimicrobial activity, secondary structure, and possible mechanism of antifungal action. Antimicrob Agents Chemother.2003, 47, 643-652.
Boman, H. G.; Hultmark, D. Cell-free immunity in insects. Annu. Rev. Microbiol.1987, 41, 103-126.
Brahmachary, M.; Krishnan, S. P.; Koh, J. L.; Khan, A. M.; Seah, S. H.; Tan, T. W.; Brusic, V.; Bajic, V. B. ANTIMIC: a database of antimicrobial sequences. Nucleic Acids Res.2004, 32, D586-589.
Bulet, P.; Cociancich, S.; Dimarcq, J. L.; Lambert, J.; Reichhart, J. M.; Hoffmann, D.; Hetru, C.; Hoffmann, J. A. Insect immunity. Isolation from a coleopteran insect of a novel inducible antibacterial peptide and of new members of the insect defensin family. J. Biol. Chem.1991, 266, 24520-24525.
Casteels, P.; Ampe, C.; Riviere, L.; Van Damme, J.; Elicone, C.; Fleming, M.; Jacobs, F.; Tempst, P. Isolation and characterization of abaecin, a major antibacterial response peptide in the honeybee (Apis mellifera). Eur. J. Biochem.1990, 187, 381-386.
Chalekson, C. P.; Neumeister, M. W.; Jaynes, J. Treatment of infected wounds with the antimicrobial peptide D2A21. J. Trauma.2003, 54, 770-774.
Chen, C.; Hu, J.; Zhang, S.; Zhou, P.; Zhao, X.; Xu, H.; Yaseen, M.; Lu, J. R. Molecular mechanisms of antibacterial and antitumor actions of designed surfactant-like peptides. Biomaterials.2012, 33, 592-603
Chernysh, S.; Kim, S. I.; Bekker, G.; Pleskach, V. A.; Filatova, N. A.; Anikin, V. B.; Platonov, V. G.; Bulet, P. Antiviral and antitumor peptides from insects. Proc. Natl .Acad. Sci. U S A.2002, 99, 12628-12632.
Chesnokova, L. S.; Slepenkov, S. V.; Witt, S. N. The insect antimicrobial peptide, L-pyrrhocoricin, binds to and stimulates the ATPase activity of both wild-type and lidless DnaK. FEBS Lett.2004, 565, 65-69.
Christensen, B.; Fink, J.; Merrifield, R. B.; Mauzerall, D. Channel-forming properties of cecropins and related model compounds incorporated into planar lipid membranes. Proc. Natl. Acad. Sci. U S A.1988, 85, 5072-5076.
Cirioni, O.; Ghiselli, R.; Silvestri, C.; Kamysz, W.; Orlando, F.; Mocchegiani, F.; Di Matteo, F.; Riva, A.; Lukasiak, J.; Scalise, G.; Saba, V.; Giacometti, A. Efficacy of tachyplesin III, colistin, and imipenem against a multiresistant Pseudomonas aeruginosa strain. Antimicrob. Agents Chemother.2007, 51, 2005-2010.
Cociancich, S.; Bulet, P.; Hetru, C.; Hoffmann, J. A. The inducible antibacterial peptides of insects. Parasitol. Today.1994, 10, 132-139.
Cociancich, S.; Ghazi, A.; Hetru, C.; Hoffmann, J. A.; Letellier, L. Insect defensin, an inducible antibacterial peptide, forms voltage-dependent channels in Micrococcus luteus. J. Biol. Chem.1993, 268, 19239-19245.
Daffre, S.; Kylsten, P.; Samakovlis, C.; Hultmark, D. The lysozyme locus in Drosophila melanogaster: an expanded gene family adapted for expression in the digestive tract. Mol. Gen. Genet.1994, 242, 152-162.
DeLucca, A. J.; Bland, J. M.; Jacks, T. J.; Grimm, C.; Cleveland, T. E.; Walsh, T. J. Fungicidal activity of cecropin A. Antimicrob. Agents Chemother.1997, 41, 481-483.
Dickinson, L.; Russell, V.; Dunn, P. E. A family of bacteria-regulated, cecropin D-like peptides from Manduca sexta. J. Biol. Chem.1988, 263, 19424-19429.
Dimarcq, J. L.; Zachary, D.; Hoffmann, J. A.; Hoffmann, D.; Reichhart, J. M. Insect immunity: expression of the two major inducible antibacterial peptides, defensin and diptericin, in Phormia terranovae. EMBO J.1990, 9, 2507-2515.
Engstrom, A.; Xanthopoulos, K. G.; Boman, H. G.; Bennich, H. Amino acid and cDNA sequences of lysozyme from Hyalophora cecropia. EMBO J.1985, 4, 2119-2122.
Fehlbaum, P.; Bulet, P.; Chernysh, S.; Briand, J. P.; Roussel, J. P.; Letellier, L.; Hetru, C.; Hoffmann, J. A. Structure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides. Proc. Natl. Acad. Sci. U S A.1996, 93, 1221-1225.
Fehlbaum, P.; Bulet, P.; Michaut, L.; Lagueux, M.; Broekaert, W. F.; Hetru, C.; Hoffmann, J. A. Insect immunity. Septic injury of Drosophila induces the synthesis of a potent antifungal peptide with sequence homology to plant antifungal peptides. J. Biol. Chem.1994, 269, 33159-33163.
Gordon, Y. J.; Romanowski, E. G.; McDermott, A. M. A review of antimicrobial peptides and their therapeutic potential as anti-infective drugs. Curr. Eye Res.2005, 30, 505-515.
Hale, J. D.; Hancock, R. E. Alternative mechanisms of action of cationic antimicrobial peptides on bacteria. Expert Rev. Anti .Infect. Ther.2007, 5, 951-959.
Hara, S.; Yamakawa, M. Moricin, a novel type of antibacterial peptide isolated from the silkworm, Bombyx mori. J. Biol. Chem.1995, 270, 29923-29927.
Harder, J.; Bartels, J.; Christophers, E.; Schroder, J. M. Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibiotic. J. Biol. Chem.2001, 276, 5707-5713.
Hetru, C.; Troxler, L.; Hoffmann, J. A. Drosophila melanogaster antimicrobial defense. J. Infect Dis.2003, 187 Suppl 2, S327-334.
Hoffmann, J. A.; Kafatos, F. C.; Janeway, C. A.; Ezekowitz, R. A. Phylogenetic perspectives in innate immunity. Science.1999, 284, 1313-1318.
Hong, R. W.; Shchepetov, M.; Weiser, J. N.; Axelsen, P. H. Transcriptional profile of the Escherichia coli response to the antimicrobial insect peptide cecropin A. Antimicrob. Agents Chemother.2003, 47, 1-6.
Huang, H. W. Action of antimicrobial peptides: two-state model. Biochemistry.2000, 39, 8347-8352.
Hultmark, D. Immune reactions in Drosophila and other insects: a model for innate immunity. Trends Genet.1993, 9, 178-183.
Hultmark, D.; Engstrom, A.; Bennich, H.; Kapur, R.; Boman, H. G. Insect immunity: isolation and structure of cecropin D and four minor antibacterial components from Cecropia pupae. Eur. J. Biochem.1982, 127, 207-217.
Hultmark, D.; Steiner, H.; Rasmuson, T.; Boman, H. G. Insect immunity. Purification and properties of three inducible bactericidal proteins from hemolymph of immunized pupae of Hyalophora cecropia. Eur. J. Biochem.1980, 106, 7-16.
Irving, P.; Troxler, L.; Heuer, T. S.; Belvin, M.; Kopczynski, C.; Reichhart, J. M.; Hoffmann, J. A.; Hetru, C. A genome-wide analysis of immune responses in Drosophila. Proc. Natl. Acad. Sci U S A.2001, 98, 15119-15124.
Jang, W. S.; Kim, K. N.; Lee, Y. S.; Nam, M. H.; Lee, I. H. Halocidin: a new antimicrobial peptide from hemocytes of the solitary tunicate, Halocynthia aurantium. FEBS Lett.2002, 521, 81-86.
Kim, I. W.; Lee, J. H.; Kwon, Y. N.; Yun, E. Y.; Nam, S. H.; Ahn, M. Y.; Kang, D. C.; Hwang, J. S. Anticancer activity of a synthetic peptide derived from harmoniasin, an antibacterial peptide from the ladybug Harmonia axyridis. Int. J. Oncol.2013, 43, 622-628.
Kockum, K.; Faye, I.; Hofsten, P. V.; Lee, J. Y.; Xanthopoulos, K. G.; Boman, H. G. Insect immunity. Isolation and sequence of two cDNA clones corresponding to acidic and basic attacins from Hyalophora cecropia. EMBO J.1984, 3, 2071-2075.
Koyama, Y.; Motobu, M.; Hikosaka, K.; Yamada, M.; Nakamura, K.; Saido-Sakanaka, H.; Asaoka, A.; Yamakawa, M.; Sekikawa, K.; Kitani, H.; Shimura, K.; Nakai, Y.; Hirota, Y. Protective effects of antimicrobial peptides derived from the beetle Allomyrina dichotoma defensin on endotoxic shock in mice. Int. Immunopharmacol.2006, 6, 234-240.
Kragol, G.; Lovas, S.; Varadi, G.; Condie, B. A.; Hoffmann, R.; Otvos, L., Jr. The antibacterial peptide pyrrhocoricin inhibits the ATPase actions of DnaK and prevents chaperone-assisted protein folding. Biochemistry.2001, 40, 3016-3026.
Lee, S. Y.; Moon, H. J.; Kurata, S.; Natori, S.; Lee, B. L. Purification and cDNA cloning of an antifungal protein from the hemolymph of Holotrichia diomphalia larvae. Biol.Pharm. Bull.1995, 18, 1049-1052.
Leuschner, C.; Enright, F. M.; Gawronska, B.; Hansel, W. Membrane disrupting lytic peptide conjugates destroy hormone dependent and independent breast cancer cells in vitro and in vivo. Breast Cancer Res. Treat.2003, 78, 17-27.
Leuschner, C.; Hansel, W. Membrane disrupting lytic peptides for cancer treatments. Curr. Pharm. Des.2004, 10, 2299-2310.
Lowenberger, C. Innate immune response of Aedes aegypti. Insect Biochem. Mol. Biol.2001, 31, 219-229.
Matejuk, A.; Leng, Q.; Begum, M. D.; Woodle, M. C.; Scaria, P.; Chou, S. T.; Mixson, A. J. Peptide-based Antifungal Therapies against Emerging Infections. Drugs Future.2010, 35, 197.
Michaut, L.; Fehlbaum, P.; Moniatte, M.; Van Dorsselaer, A.; Reichhart, J. M.; Bulet, P. Determination of the disulfide array of the first inducible antifungal peptide from insects: drosomycin from Drosophila melanogaster. FEBS Lett.1996, 395, 6-10.
Otvos, L., Jr. The short proline-rich antibacterial peptide family. Cell Mol. Life Sci.2002, 59, 1138-1150.
Papo, N.; Shai, Y. New lytic peptides based on the D,L-amphipathic helix motif preferentially kill tumor cells compared to normal cells. Biochemistry.2003, 42, 9346-9354.
Park, C. B.; Kim, H. S.; Kim, S. C. Mechanism of action of the antimicrobial peptide buforin II: buforin II kills microorganisms by penetrating the cell membrane and inhibiting cellular functions. Biochem. Biophys. Res. Commun.1998, 244, 253-257.
Peters, B. M.; Shirtliff, M. E.; Jabra-Rizk, M. A. Antimicrobial peptides: primeval molecules or future drugs? PLoS Pathog.2010, 6, e1001067.
Rees, J. A.; Moniatte, M.; Bulet, P. Novel antibacterial peptides isolated from a European bumblebee, Bombus pascuorum (Hymenoptera, Apoidea). Insect Biochem. Mol. Biol.1997, 27, 413-422.
Seshadri Sundararajan, V.; Gabere, M. N.; Pretorius, A.; Adam, S.; Christoffels, A.; Lehvaslaiho, M.; Archer, J. A.; Bajic, V. B. DAMPD: a manually curated antimicrobial peptide database. Nucleic Acids Res.2012, 40, D1108-1112.
Shen, L.; Liu, D.; Li, M.; Jin, F.; Din, M.; Parnell, L. D.; Lai, C. Q. Mechanism of action of recombinant acc-royalisin from royal jelly of Asian honeybee against gram-positive bacteria. PLoS One.2012, 7, e47194.
Sondergaard, L. Homology between the mammalian liver and the Drosophila fat body. Trends. Genet.1993, 9, 193.
Sousa, L. B.; Mannis, M. J.; Schwab, I. R.; Cullor, J.; Hosotani, H.; Smith, W.; Jaynes, J. The use of synthetic Cecropin (D5C) in disinfecting contact lens solutions. CLAO J.1996, 22, 114-117.
Steiner, H.; Hultmark, D.; Engstrom, A.; Bennich, H.; Boman, H. G. Sequence and specificity of two antibacterial proteins involved in insect immunity. Nature.1981, 292, 246-248.
Tian, C.; Gao, B.; Fang, Q.; Ye, G.; Zhu, S. Antimicrobial peptide-like genes in Nasonia vitripennis: a genomic perspective. BMC Genomics.2010, 11, 187.
Upton, M.; Cotter, P.; Tagg, J. Antimicrobial peptides as therapeutic agents. Int. J. Microbiol.2012, 2012, 326503.
Van den Bogaart, G.; Guzman, J. V.; Mika, J. T.; Poolman, B. On the mechanism of pore formation by melittin. J. Biol. Chem.2008, 283, 33854-33857.
Vilmos, P.; Kurucz, E. Insect immunity: evolutionary roots of the mammalian innate immune system. Immunol. Lett.1998, 62, 59-66.
Wachinger, M.; Kleinschmidt, A.; Winder, D.; von Pechmann, N.; Ludvigsen, A.; Neumann, M.; Holle, R.; Salmons, B.; Erfle, V.; Brack-Werner, R. Antimicrobial peptides melittin and cecropin inhibit replication of human immunodeficiency virus 1 by suppressing viral gene expression. J. Gen. Virol.1998, 79 ( Pt 4), 731-740.
Wang, K.; Yan, J.; Dang, W.; Liu, X.; Chen, R.; Zhang, J.; Zhang, B.; Zhang, W.; Kai, M.; Yan, W.; Yang, Z.; Xie, J.; Wang, R. Membrane active antimicrobial activity and molecular dynamics study of a novel cationic antimicrobial peptide polybia-MPI, from the venom of Polybia paulista. Peptides.2013, 39, 80-88.
Wang, Y. P.; Lai, R. [Insect antimicrobial peptides: structures, properties and gene regulation]. Dongwuxue Yanjiu.2010, 31, 27-34.
Wang, Z.; Wang, G. APD: the Antimicrobial Peptide Database. Nucleic Acids Res.2004, 32, D590-592.
Wicker, C.; Reichhart, J. M.; Hoffmann, D.; Hultmark, D.; Samakovlis, C.; Hoffmann, J. A. Insect immunity. Characterization of a Drosophila cDNA encoding a novel member of the diptericin family of immune peptides. J. Biol. Chem.1990, 265, 22493-22498.
Wimley, W. C. Describing the mechanism of antimicrobial peptide action with the interfacial activity model. ACS Chem. Biol.2010, 5, 905-917.
Yamada, K.; Natori, S. Characterization of the antimicrobial peptide derived from sapecin B, an antibacterial protein of Sarcophaga peregrina (flesh fly). Biochem. J.1994, 298 Pt 3, 623-628.
Yamada, M.; Nakamura, K.; Saido-Sakanaka, H.; Asaoka, A.; Yamakawa, M.; Yamamoto, Y.; Koyama, Y.; Hikosaka, K.; Shimizu, A.; Hirota, Y. Therapeutic effect of modified oligopeptides from the beetle Allomyrina dichotoma on methicillin-resistant Staphylococcus aureus (MRSA) infection in mice. J. Vet. Med. Sci.2005, 67, 1005-1011.
Yeaman, M. R.; Yount, N. Y. Mechanisms of antimicrobial peptide action and resistance. Pharmacol.Rev.2003, 55, 27-55.
Zasloff, M. Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc. Natl. Acad. Sci. U S A.1987, 84, 5449-5453.
Zeitler, B.; Herrera Diaz, A.; Dangel, A.; Thellmann, M.; Meyer, H.; Sattler, M.; Lindermayr, C. De-novo design of antimicrobial peptides for plant protection. PLoS One.2013, 8, e71687.
Zhang, L.; Benz, R.; Hancock, R. E. Influence of proline residues on the antibacterial and synergistic activities of alpha-helical peptides. Biochemistry.1999, 38, 8102-8111.
Zwaal, R. F.; Schroit, A. J. Pathophysiologic implications of membrane phospholipid asymmetry in blood cells. Blood.1997, 89, 1121-1132.
Baghian, A.; Jaynes, J.; Enright, F.; Kousoulas, K. G. An amphipathic alpha-helical synthetic peptide analogue of melittin inhibits herpes simplex virus-1 (HSV-1)-induced cell fusion and virus spread. Peptides.1997, 18, 177-183.
Bobek, L. A.; Situ, H. MUC7 20-Mer: investigation of antimicrobial activity, secondary structure, and possible mechanism of antifungal action. Antimicrob Agents Chemother.2003, 47, 643-652.
Boman, H. G.; Hultmark, D. Cell-free immunity in insects. Annu. Rev. Microbiol.1987, 41, 103-126.
Brahmachary, M.; Krishnan, S. P.; Koh, J. L.; Khan, A. M.; Seah, S. H.; Tan, T. W.; Brusic, V.; Bajic, V. B. ANTIMIC: a database of antimicrobial sequences. Nucleic Acids Res.2004, 32, D586-589.
Bulet, P.; Cociancich, S.; Dimarcq, J. L.; Lambert, J.; Reichhart, J. M.; Hoffmann, D.; Hetru, C.; Hoffmann, J. A. Insect immunity. Isolation from a coleopteran insect of a novel inducible antibacterial peptide and of new members of the insect defensin family. J. Biol. Chem.1991, 266, 24520-24525.
Casteels, P.; Ampe, C.; Riviere, L.; Van Damme, J.; Elicone, C.; Fleming, M.; Jacobs, F.; Tempst, P. Isolation and characterization of abaecin, a major antibacterial response peptide in the honeybee (Apis mellifera). Eur. J. Biochem.1990, 187, 381-386.
Chalekson, C. P.; Neumeister, M. W.; Jaynes, J. Treatment of infected wounds with the antimicrobial peptide D2A21. J. Trauma.2003, 54, 770-774.
Chen, C.; Hu, J.; Zhang, S.; Zhou, P.; Zhao, X.; Xu, H.; Yaseen, M.; Lu, J. R. Molecular mechanisms of antibacterial and antitumor actions of designed surfactant-like peptides. Biomaterials.2012, 33, 592-603
Chernysh, S.; Kim, S. I.; Bekker, G.; Pleskach, V. A.; Filatova, N. A.; Anikin, V. B.; Platonov, V. G.; Bulet, P. Antiviral and antitumor peptides from insects. Proc. Natl .Acad. Sci. U S A.2002, 99, 12628-12632.
Chesnokova, L. S.; Slepenkov, S. V.; Witt, S. N. The insect antimicrobial peptide, L-pyrrhocoricin, binds to and stimulates the ATPase activity of both wild-type and lidless DnaK. FEBS Lett.2004, 565, 65-69.
Christensen, B.; Fink, J.; Merrifield, R. B.; Mauzerall, D. Channel-forming properties of cecropins and related model compounds incorporated into planar lipid membranes. Proc. Natl. Acad. Sci. U S A.1988, 85, 5072-5076.
Cirioni, O.; Ghiselli, R.; Silvestri, C.; Kamysz, W.; Orlando, F.; Mocchegiani, F.; Di Matteo, F.; Riva, A.; Lukasiak, J.; Scalise, G.; Saba, V.; Giacometti, A. Efficacy of tachyplesin III, colistin, and imipenem against a multiresistant Pseudomonas aeruginosa strain. Antimicrob. Agents Chemother.2007, 51, 2005-2010.
Cociancich, S.; Bulet, P.; Hetru, C.; Hoffmann, J. A. The inducible antibacterial peptides of insects. Parasitol. Today.1994, 10, 132-139.
Cociancich, S.; Ghazi, A.; Hetru, C.; Hoffmann, J. A.; Letellier, L. Insect defensin, an inducible antibacterial peptide, forms voltage-dependent channels in Micrococcus luteus. J. Biol. Chem.1993, 268, 19239-19245.
Daffre, S.; Kylsten, P.; Samakovlis, C.; Hultmark, D. The lysozyme locus in Drosophila melanogaster: an expanded gene family adapted for expression in the digestive tract. Mol. Gen. Genet.1994, 242, 152-162.
DeLucca, A. J.; Bland, J. M.; Jacks, T. J.; Grimm, C.; Cleveland, T. E.; Walsh, T. J. Fungicidal activity of cecropin A. Antimicrob. Agents Chemother.1997, 41, 481-483.
Dickinson, L.; Russell, V.; Dunn, P. E. A family of bacteria-regulated, cecropin D-like peptides from Manduca sexta. J. Biol. Chem.1988, 263, 19424-19429.
Dimarcq, J. L.; Zachary, D.; Hoffmann, J. A.; Hoffmann, D.; Reichhart, J. M. Insect immunity: expression of the two major inducible antibacterial peptides, defensin and diptericin, in Phormia terranovae. EMBO J.1990, 9, 2507-2515.
Engstrom, A.; Xanthopoulos, K. G.; Boman, H. G.; Bennich, H. Amino acid and cDNA sequences of lysozyme from Hyalophora cecropia. EMBO J.1985, 4, 2119-2122.
Fehlbaum, P.; Bulet, P.; Chernysh, S.; Briand, J. P.; Roussel, J. P.; Letellier, L.; Hetru, C.; Hoffmann, J. A. Structure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides. Proc. Natl. Acad. Sci. U S A.1996, 93, 1221-1225.
Fehlbaum, P.; Bulet, P.; Michaut, L.; Lagueux, M.; Broekaert, W. F.; Hetru, C.; Hoffmann, J. A. Insect immunity. Septic injury of Drosophila induces the synthesis of a potent antifungal peptide with sequence homology to plant antifungal peptides. J. Biol. Chem.1994, 269, 33159-33163.
Gordon, Y. J.; Romanowski, E. G.; McDermott, A. M. A review of antimicrobial peptides and their therapeutic potential as anti-infective drugs. Curr. Eye Res.2005, 30, 505-515.
Hale, J. D.; Hancock, R. E. Alternative mechanisms of action of cationic antimicrobial peptides on bacteria. Expert Rev. Anti .Infect. Ther.2007, 5, 951-959.
Hara, S.; Yamakawa, M. Moricin, a novel type of antibacterial peptide isolated from the silkworm, Bombyx mori. J. Biol. Chem.1995, 270, 29923-29927.
Harder, J.; Bartels, J.; Christophers, E.; Schroder, J. M. Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibiotic. J. Biol. Chem.2001, 276, 5707-5713.
Hetru, C.; Troxler, L.; Hoffmann, J. A. Drosophila melanogaster antimicrobial defense. J. Infect Dis.2003, 187 Suppl 2, S327-334.
Hoffmann, J. A.; Kafatos, F. C.; Janeway, C. A.; Ezekowitz, R. A. Phylogenetic perspectives in innate immunity. Science.1999, 284, 1313-1318.
Hong, R. W.; Shchepetov, M.; Weiser, J. N.; Axelsen, P. H. Transcriptional profile of the Escherichia coli response to the antimicrobial insect peptide cecropin A. Antimicrob. Agents Chemother.2003, 47, 1-6.
Huang, H. W. Action of antimicrobial peptides: two-state model. Biochemistry.2000, 39, 8347-8352.
Hultmark, D. Immune reactions in Drosophila and other insects: a model for innate immunity. Trends Genet.1993, 9, 178-183.
Hultmark, D.; Engstrom, A.; Bennich, H.; Kapur, R.; Boman, H. G. Insect immunity: isolation and structure of cecropin D and four minor antibacterial components from Cecropia pupae. Eur. J. Biochem.1982, 127, 207-217.
Hultmark, D.; Steiner, H.; Rasmuson, T.; Boman, H. G. Insect immunity. Purification and properties of three inducible bactericidal proteins from hemolymph of immunized pupae of Hyalophora cecropia. Eur. J. Biochem.1980, 106, 7-16.
Irving, P.; Troxler, L.; Heuer, T. S.; Belvin, M.; Kopczynski, C.; Reichhart, J. M.; Hoffmann, J. A.; Hetru, C. A genome-wide analysis of immune responses in Drosophila. Proc. Natl. Acad. Sci U S A.2001, 98, 15119-15124.
Jang, W. S.; Kim, K. N.; Lee, Y. S.; Nam, M. H.; Lee, I. H. Halocidin: a new antimicrobial peptide from hemocytes of the solitary tunicate, Halocynthia aurantium. FEBS Lett.2002, 521, 81-86.
Kim, I. W.; Lee, J. H.; Kwon, Y. N.; Yun, E. Y.; Nam, S. H.; Ahn, M. Y.; Kang, D. C.; Hwang, J. S. Anticancer activity of a synthetic peptide derived from harmoniasin, an antibacterial peptide from the ladybug Harmonia axyridis. Int. J. Oncol.2013, 43, 622-628.
Kockum, K.; Faye, I.; Hofsten, P. V.; Lee, J. Y.; Xanthopoulos, K. G.; Boman, H. G. Insect immunity. Isolation and sequence of two cDNA clones corresponding to acidic and basic attacins from Hyalophora cecropia. EMBO J.1984, 3, 2071-2075.
Koyama, Y.; Motobu, M.; Hikosaka, K.; Yamada, M.; Nakamura, K.; Saido-Sakanaka, H.; Asaoka, A.; Yamakawa, M.; Sekikawa, K.; Kitani, H.; Shimura, K.; Nakai, Y.; Hirota, Y. Protective effects of antimicrobial peptides derived from the beetle Allomyrina dichotoma defensin on endotoxic shock in mice. Int. Immunopharmacol.2006, 6, 234-240.
Kragol, G.; Lovas, S.; Varadi, G.; Condie, B. A.; Hoffmann, R.; Otvos, L., Jr. The antibacterial peptide pyrrhocoricin inhibits the ATPase actions of DnaK and prevents chaperone-assisted protein folding. Biochemistry.2001, 40, 3016-3026.
Lee, S. Y.; Moon, H. J.; Kurata, S.; Natori, S.; Lee, B. L. Purification and cDNA cloning of an antifungal protein from the hemolymph of Holotrichia diomphalia larvae. Biol.Pharm. Bull.1995, 18, 1049-1052.
Leuschner, C.; Enright, F. M.; Gawronska, B.; Hansel, W. Membrane disrupting lytic peptide conjugates destroy hormone dependent and independent breast cancer cells in vitro and in vivo. Breast Cancer Res. Treat.2003, 78, 17-27.
Leuschner, C.; Hansel, W. Membrane disrupting lytic peptides for cancer treatments. Curr. Pharm. Des.2004, 10, 2299-2310.
Lowenberger, C. Innate immune response of Aedes aegypti. Insect Biochem. Mol. Biol.2001, 31, 219-229.
Matejuk, A.; Leng, Q.; Begum, M. D.; Woodle, M. C.; Scaria, P.; Chou, S. T.; Mixson, A. J. Peptide-based Antifungal Therapies against Emerging Infections. Drugs Future.2010, 35, 197.
Michaut, L.; Fehlbaum, P.; Moniatte, M.; Van Dorsselaer, A.; Reichhart, J. M.; Bulet, P. Determination of the disulfide array of the first inducible antifungal peptide from insects: drosomycin from Drosophila melanogaster. FEBS Lett.1996, 395, 6-10.
Otvos, L., Jr. The short proline-rich antibacterial peptide family. Cell Mol. Life Sci.2002, 59, 1138-1150.
Papo, N.; Shai, Y. New lytic peptides based on the D,L-amphipathic helix motif preferentially kill tumor cells compared to normal cells. Biochemistry.2003, 42, 9346-9354.
Park, C. B.; Kim, H. S.; Kim, S. C. Mechanism of action of the antimicrobial peptide buforin II: buforin II kills microorganisms by penetrating the cell membrane and inhibiting cellular functions. Biochem. Biophys. Res. Commun.1998, 244, 253-257.
Peters, B. M.; Shirtliff, M. E.; Jabra-Rizk, M. A. Antimicrobial peptides: primeval molecules or future drugs? PLoS Pathog.2010, 6, e1001067.
Rees, J. A.; Moniatte, M.; Bulet, P. Novel antibacterial peptides isolated from a European bumblebee, Bombus pascuorum (Hymenoptera, Apoidea). Insect Biochem. Mol. Biol.1997, 27, 413-422.
Seshadri Sundararajan, V.; Gabere, M. N.; Pretorius, A.; Adam, S.; Christoffels, A.; Lehvaslaiho, M.; Archer, J. A.; Bajic, V. B. DAMPD: a manually curated antimicrobial peptide database. Nucleic Acids Res.2012, 40, D1108-1112.
Shen, L.; Liu, D.; Li, M.; Jin, F.; Din, M.; Parnell, L. D.; Lai, C. Q. Mechanism of action of recombinant acc-royalisin from royal jelly of Asian honeybee against gram-positive bacteria. PLoS One.2012, 7, e47194.
Sondergaard, L. Homology between the mammalian liver and the Drosophila fat body. Trends. Genet.1993, 9, 193.
Sousa, L. B.; Mannis, M. J.; Schwab, I. R.; Cullor, J.; Hosotani, H.; Smith, W.; Jaynes, J. The use of synthetic Cecropin (D5C) in disinfecting contact lens solutions. CLAO J.1996, 22, 114-117.
Steiner, H.; Hultmark, D.; Engstrom, A.; Bennich, H.; Boman, H. G. Sequence and specificity of two antibacterial proteins involved in insect immunity. Nature.1981, 292, 246-248.
Tian, C.; Gao, B.; Fang, Q.; Ye, G.; Zhu, S. Antimicrobial peptide-like genes in Nasonia vitripennis: a genomic perspective. BMC Genomics.2010, 11, 187.
Upton, M.; Cotter, P.; Tagg, J. Antimicrobial peptides as therapeutic agents. Int. J. Microbiol.2012, 2012, 326503.
Van den Bogaart, G.; Guzman, J. V.; Mika, J. T.; Poolman, B. On the mechanism of pore formation by melittin. J. Biol. Chem.2008, 283, 33854-33857.
Vilmos, P.; Kurucz, E. Insect immunity: evolutionary roots of the mammalian innate immune system. Immunol. Lett.1998, 62, 59-66.
Wachinger, M.; Kleinschmidt, A.; Winder, D.; von Pechmann, N.; Ludvigsen, A.; Neumann, M.; Holle, R.; Salmons, B.; Erfle, V.; Brack-Werner, R. Antimicrobial peptides melittin and cecropin inhibit replication of human immunodeficiency virus 1 by suppressing viral gene expression. J. Gen. Virol.1998, 79 ( Pt 4), 731-740.
Wang, K.; Yan, J.; Dang, W.; Liu, X.; Chen, R.; Zhang, J.; Zhang, B.; Zhang, W.; Kai, M.; Yan, W.; Yang, Z.; Xie, J.; Wang, R. Membrane active antimicrobial activity and molecular dynamics study of a novel cationic antimicrobial peptide polybia-MPI, from the venom of Polybia paulista. Peptides.2013, 39, 80-88.
Wang, Y. P.; Lai, R. [Insect antimicrobial peptides: structures, properties and gene regulation]. Dongwuxue Yanjiu.2010, 31, 27-34.
Wang, Z.; Wang, G. APD: the Antimicrobial Peptide Database. Nucleic Acids Res.2004, 32, D590-592.
Wicker, C.; Reichhart, J. M.; Hoffmann, D.; Hultmark, D.; Samakovlis, C.; Hoffmann, J. A. Insect immunity. Characterization of a Drosophila cDNA encoding a novel member of the diptericin family of immune peptides. J. Biol. Chem.1990, 265, 22493-22498.
Wimley, W. C. Describing the mechanism of antimicrobial peptide action with the interfacial activity model. ACS Chem. Biol.2010, 5, 905-917.
Yamada, K.; Natori, S. Characterization of the antimicrobial peptide derived from sapecin B, an antibacterial protein of Sarcophaga peregrina (flesh fly). Biochem. J.1994, 298 Pt 3, 623-628.
Yamada, M.; Nakamura, K.; Saido-Sakanaka, H.; Asaoka, A.; Yamakawa, M.; Yamamoto, Y.; Koyama, Y.; Hikosaka, K.; Shimizu, A.; Hirota, Y. Therapeutic effect of modified oligopeptides from the beetle Allomyrina dichotoma on methicillin-resistant Staphylococcus aureus (MRSA) infection in mice. J. Vet. Med. Sci.2005, 67, 1005-1011.
Yeaman, M. R.; Yount, N. Y. Mechanisms of antimicrobial peptide action and resistance. Pharmacol.Rev.2003, 55, 27-55.
Zasloff, M. Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc. Natl. Acad. Sci. U S A.1987, 84, 5449-5453.
Zeitler, B.; Herrera Diaz, A.; Dangel, A.; Thellmann, M.; Meyer, H.; Sattler, M.; Lindermayr, C. De-novo design of antimicrobial peptides for plant protection. PLoS One.2013, 8, e71687.
Zhang, L.; Benz, R.; Hancock, R. E. Influence of proline residues on the antibacterial and synergistic activities of alpha-helical peptides. Biochemistry.1999, 38, 8102-8111.
Zwaal, R. F.; Schroit, A. J. Pathophysiologic implications of membrane phospholipid asymmetry in blood cells. Blood.1997, 89, 1121-1132.
Published
2022-02-06
How to Cite
Osama AO Elhag, & Manal Ismaiel. (2022). The Insects Antimicrobial Peptides’ Properties, Importance and Mode of Action. Journal of The Faculty of Science and Technology, (8), 1 - 16. https://doi.org/10.52981/jfst.vi8.1951
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Articles
