Comparison between Fructose Amine and Hemoglobin A1C Level to Evaluate Glycemic Control in Sudanese Diabetic Control.

Abdelsamee   Elobied Mohamed Elamin; Ahmed  Mahdi Fadlallah Elneeima

doi:10.52981/oiuj.v18i1.2037

Abdelsamee Elobied Mohamed Elamin Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, Omdurman Islamic University, Omdurman, Sudan
Ahmed Mahdi Fadlallah Elneeima Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, Omdurman Islamic University, Omdurman, Sudan

DOI: https://doi.org/10.52981/oiuj.v18i1.2037

الكلمات المفتاحية: Diabetes, Controlled, fructosamine, HbA1c, Sudan

الملخص

Background: Diabetes mellitus (DM), commonly referred to as diabetes, is a group of metabolic diseases with high blood sugar levels over a prolonged period, and is one of the most severe and frequent human disorders. Fructosamine is a generic name given to a compound known as plasma protein ketoamines. Fructosamine together with glycated haemoglobin (HbA1c) are used to monitor the state of hyperglycaemia in diabetics.

Objectives: This study aimed to compare between HeamoglobinA1c and Fructosamine in Sudanese diabetic patients in Omdurman Teaching Hospital and Diabetic and Endocrine center in Bahri.

Materials and Methods: This is a cross-sectional study. Automated colorimetric determination of fructosamine for each of the 50 blood samples of the study group was carried out according to specific procedure. Latex enhanced immuno-assay method for hemoglobinA1c (HbA1c) determination based on the interaction between antigen molecules (HbA1c) and HbA1c specific c antibodies coated on latex beads was carried out according to a specific procedure. Control group criteria should be clear because it is confused.

Results: HbA1c% and Fructose amine were measured on the same sample in 50 diabetic patients. There is a significantly direct positive correlation between levels of fructose amine (mmol/L) and HbA1c% among the studied group (P-value = 0.001 < 0.05). Sensitivity and specificity of fructosamine and HbA1c to detect blood glucose. hemoglobin A1C has (86%) sensitivity and (25%) specificity while fructosamine has (63%) sensitivity and (55%) specificity.

Conclusion:

In diabetes serum fructosamine assay can better reflect average blood glucose concentration over the previous 2-3 weeks and HbA1_c is better reflective over the previous 8-10 weeks there for fructosamine can be used as routine test while HbA1C as a first -line screening test.

السير الشخصية للمؤلفين

Abdelsamee Elobied Mohamed Elamin، Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, Omdurman Islamic University, Omdurman, Sudan

Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, Omdurman Islamic University, Omdurman, Sudan

Ahmed Mahdi Fadlallah Elneeima، Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, Omdurman Islamic University, Omdurman, Sudan

Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, Omdurman Islamic University, Omdurman, Sudan

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