Prevalence of the Autoantibody Anti-dsDNA Antibody in Recurrent Aborted Women in Khartoum-Sudan
Keywords:
dsDNA, SLE, abortion, Sudanese women, ELISA
Abstract
Background: An autoimmune effect and associated immunological changes subsequent in recurrent abortion. Autoantibodies and complement activation lead to multisystem tissue damage have been proposed in patients with unidentified etiology. Pregnant females with SLE considered at high risk of recurrent abortion.
Objectives: This study aimed to determine the frequency of autoantibody dsDNA among aborted women in Omdurman Maternity Hospital.
Methods: Cross sectional study to detect the presence of anti dsDNA antibody in the serum of aborted women in Omdurman Maternity Hospital using ELISA technique.
Result: A total of 83 aborted women enrolled in the study were negative for anti dsDNA antibody. Conclusion: This study revealed that there are no significant correlation between SLE and abortion among aborted Sudanese women.
References
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11.Conti F, Ceccarelli F, Perricone C, Massaro L, Marocchi E, Miranda F, et al. Systemic Lupus Erythematosus with and without Anti-dsDNA Antibodies: Analysis from a Large Monocentric Cohort. Mediators of inflammation. 2015;2015:328078.
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16.Lee SM, Lee EM, Park JK, Jeon HS, Oh S, Hong S, et al. Metabolic Biomarkers In Midtrimester Maternal Plasma Can Accurately Predict Adverse Pregnancy Outcome in Patients with SLE. Scientific reports. 2019;9(1):15169.
17.Shankarkumar U, Pradhan VD, Patwardhan MM, Shankarkumar A, Ghosh K. Autoantibody profile and other immunological parameters in recurrent spontaneous abortion patients. Nigerian medical journal : journal of the Nigeria Medical Association. 2011;52(3):163-6.
2. Wu L, Cheng B, Liu Q, Jiang P, Yang J. CRY2 suppresses trophoblast migration and invasion in recurrent spon-taneous abortion. Journal of biochemistry. 2020; 167(1):79-87.
3. Sereshki N, Andalib A, Ghahiri A, Mehrabian F, Sherkat R, Rezaei A. Can the Decreased Expression of Human Leukocyte Antigen Cl-ass and by Spermatozoa Lead to Recurrent Spontaneous Abo-rtion? Iranian journal of pathology. 2020; 15(1):19-22.
4. Zhao X, Li Q, Yu F, Lin L, Yin W, Li J, et al. Gene polymorphism associated with endothelial nitric oxide synthase (4VNTR, G894T, C786T) and unexplained recurrent spon-taneous abortion risk:Ametaanalysis.Medicine.2019;98(4):e141 75.
5. Song J, Wang X, Guo Y, Yang Y, Xu K, Wang T,etal.Novel high coverage targeted metabolomics method (SWATHtoMRM) for exploring follicular fluid metabolome alterations in women with recurrent spontaneous abortion undergoing in vitro fertilization. Scientific reports. 2019; 9(1): 10873.
6. Fan J, Zhong Y, Chen C. Impacts of Anti-dsDNA Antibody on In Vitro Fertilization-Embryo Transfer and Frozen-Thawed Embryo Transfer. Journal of immunology research. 2017;2017:8596181.
7. Yanase K, Madaio MP. Nuclear localizing anti-DNA antibodies enter cells via caveoli and modulate expression of caveolin and p53. Journal of autoimmunity. 2005;24(2):145-51.
8. Tsai CY, Hsieh SC, Lu CS, Wu TH, Liao HT, Wu CH, et al. Cross-Talk between Mitochondrial Dysfunction Provoked Oxidative Stressand Aberrant dffffffry6re``````1Noncoding RNA Expression in the Pathogenesis and Pathophysiology of SLE. International journal of molecular sciences. 2019;20(20).
9. Grabinger T, Peterburs P, Brunner T. dsDNA ASCs for caspase 8-mediated apoptosis. Cell death and differentiation. 2013;20(9):1128-30.
10.Chung SA, Nititham J, Elboudwarej E, Quach HL, Taylor KE, Barcellos LF, et al. Genome-Wide Assessment of Differential DNA Methylation Associated with Autoantibody Production in Systemic Lupus Erythematosus. PloS one. 2015;10(7):e0129813.
11.Conti F, Ceccarelli F, Perricone C, Massaro L, Marocchi E, Miranda F, et al. Systemic Lupus Erythematosus with and without Anti-dsDNA Antibodies: Analysis from a Large Monocentric Cohort. Mediators of inflammation. 2015;2015:328078.
12.Fu SM, Dai C, Zhao Z, Gaskin F. Anti-dsDNA Antibodies are one of the many autoantibodies in systemic lupus erythematosus. F1000Research. 2015;4(F1000 Faculty Rev):939.
13.Pons-Estel GJ, Alarcon GS, Scofield L, Reinlib L, Cooper GS. Understanding the epidemiology and progression of systemic lupus erythematosus. Seminars in arthritis and rheumatism. 2010; 39(4): 257-68.
14.Harris VM, Koelsch KA, Kurien BT, Harley ITW, Wren JD, Harley JB, et al. Characterization of cxorf21 Provides Molecular Insight Into Female-Bias Immune Response in SLE Pathogenesis. Frontiers in immunology. 2019;10:2160.
15.Arbuckle MR, McClain MT, Rubertone MV, Scofield RH, Dennis GJ, James JA, et al. Development of autoantibodies before the clinical onset of systemic lupus erythematosus. The New England journal of medicine. 2003;349(16):1526-33.
16.Lee SM, Lee EM, Park JK, Jeon HS, Oh S, Hong S, et al. Metabolic Biomarkers In Midtrimester Maternal Plasma Can Accurately Predict Adverse Pregnancy Outcome in Patients with SLE. Scientific reports. 2019;9(1):15169.
17.Shankarkumar U, Pradhan VD, Patwardhan MM, Shankarkumar A, Ghosh K. Autoantibody profile and other immunological parameters in recurrent spontaneous abortion patients. Nigerian medical journal : journal of the Nigeria Medical Association. 2011;52(3):163-6.
Published
2021-09-15
Section
Articles
