Body Mass Index (BMI) as Risk Factor for Developing Hypogonadism among Sudanese Patient with Chronic Kidney Disease

Rabie Elagib  Abdallah; Amani Salah  Ahmad; Esraa Mohamed  Ibrahim; Hanna Mohamed  Elrofaie; Mayada Adil  Abbas; Missa Margany  Jamal

doi:10.52981/smlj.v9i1.2574

Rabie Elagib Abdallah Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, Omdurman Islamic University, Sudan
Amani Salah Ahmad 1Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, Omdurman Islamic University, Sudan
Esraa Mohamed Ibrahim Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, Omdurman Islamic University, Sudan
Hanna Mohamed Elrofaie Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, Omdurman Islamic University, Sudan
Mayada Adil Abbas Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, Omdurman Islamic University, Sudan
Missa Margany Jamal Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, Omdurman Islamic University, Sudan

DOI: https://doi.org/10.52981/smlj.v9i1.2574

Keywords: CKD, testosterone, BMI, hypogonadism.

Abstract

Background: CKD, beside its heterogeneous clinical disorders, it is the general term used for describing an irreversible loss of kidney function, that develops due to multifactorial etiology over a period of few years, with prevalence rate between 11%-13% globally and 5%-7% locally. So the aim of this study was designed to investigate the association of the serum testosterone in patient with CKD.

Methods: The study was conducted at the Military Hospital, Police Hospital and the Kidney Transplantation Association. A case-control study was completed within the six months; i. e. from November 2017 to April 2018. The study was carried out on a total sample of 80 subjects, including 40 CKD patients as case and 40 healthy individuals as control group. The serum testosterone was estimated using ELISA technique, and the data was analyzed statistically using the Microsoft SPSS^® program version 21.

Results: this study revealed that testosterone level had decreased significantly in CKD patient in comparison to the control group, (p-value 0.041). Furthermore, BMI also had a significant impact on testosterone level, (p-value 0.013).

Conclusion: This study has showed that, the patients had developed hypogonadism as a result of CKD, together with the increasing BMI.

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