Prolactin measurements in follicular fluid; a possible role in Sudanese women with polycystic ovary syndrome.

  • Etayeb Mohamed Ahmed Tayrab Faculty of Medical Laboratory Sciences, the National Ribat University-Khartoum-Sudan
  • Ashmaig, A Faculty of Medicine the National Ribat University-Sudan
  • Kattab, A. H University of Khartoum, Faculty of Medicine-Sudan
  • Alobeid, M. H Faculty of Medicine the National Ribat University-Sudan
Keywords: Prolactin, follicular fluid, polycystic ovary syndrome

Abstract

Increasing number of polycystic ovary syndrome (PCOS) among the Sudanese women, and its sequences in infertility and other complications. Objectives of this study are to determine the prolactin hormone changes occurring in the follicular fluid in Sudanese women with PCOS. One hundred eleven Sudanese women aged 20-43 years were enrolled in the study; 55 women with PCOS and 56 women with normal ovaries. The study was carried out in the Faculty of Medicine in the National Ribat University, during the period from July 2004- May 2008. The follicular prolactin measured in PCOS patients were compared with those measured in the control group, after detailed history and clinical examination. Follicular prolactin showed significant increase (p = 0.00); in the patients with PCOS, when compared with their controls. In conclusion the biochemical parameter (prolactin) measured in this study, was strongly correlated with the PCOS, and so the prolactin assay was suggested, as one of the means of its laboratory diagnosis.

References

1. Cowden, E. (1979). Laboratory assessment of prolactin status. Ann Clin Biochem; 16: 113-1121.
2. Vankrieken, L. (2000). Immulite reproductive hormone assays multicenter reference range data. Los Angeles: diagnostic products corporation; document No (2B157-D).
3. Shauna, C. Anderson and Susan Cockayne. (1993). Clinical chemistry, concepts and applications.W.B. Saunders. p. 140-164, 553-569, 605-612.
4. Ricardo, A. Enrico, C. Didier, D. Evanthia, D-K. Hector F. Escobar, M. Walter, F. Onno, E. Janssen, R. S. Legro, R. Norman, A. Taylor, E. Selma F. and Witchel, J. (2006). Position statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an androgen excess society guideline. J Clin Endocrinol Metab; 91 (11): 4237-4245.
5. Michael, L. B. Janet L. Duben-Engelkirk, Edward, P. F. (2000). Clinical chemistry principles, procedure, correlations. 4th edn. Lippincott Williams and Wilkins:.p.322- 330
6. Michael L. B, Edward P. F. and Larry E. S. (2004). Clinical chemistry principles, procedure, correlations. 5th edn. Lippincott Williams and Wilkins:.p.215-231,322-331, 373-401.
7. Michael, T. Sheehan. (2004). Polycystic ovarian syndrome: diagnosis and management. Clin Med Res; 2(1): 13–27.
8. Martin, A. and Zilva, C. (2006). Clinical chemistry and metabolic medicine. 7th edn; Edward Arnold publishers Ltd.
9. Luciano, A. A. Chapler, F. K. Sherman, B. M. (1984). Hyperprolactinemia in polycystic ovary syndrome. Fertil Steril.; 41: 719-725.
10. Franks, S. (1989). Polycystic ovary syndrome: a changing perspective. Clin Endocrinol (Oxf); 31:87-120.
11. Milewicz, A. (1984). Prolactin levels in polycystic ovary syndrome. J Rerod Med,; 29 (3): 193-206
12. Minakami, H. Abe, N. Oka, N. Kimura, K. Tamura, T. (1988). Prolactin release in polycystic ovarian syndrome. Endocrinol Jpn,; 35 (2) 303-410.
Published
2022-10-13