Iron profile and some hematological parameters among Sudanese patients with Rheumatoid Arthritis at Khartoum state

Rouaa Babikir  Ahmed; Khalid Mohamed Khalid  Elhussain; Babiker Ahmed  Mohammed; Doaa Abdullah  Gasim; Elyasaa Ahmed Gubartalla  Ali; Manal Mohammed Khalid  Elhussien; Nora Nahal  Bouderba; Mohammed Babiker  Omer

doi:10.52981/smlj.v10i1.2768

Rouaa Babikir Ahmed Omdurman Islamic University, Faculty of Medical laboratory sciences, Sudan
Khalid Mohamed Khalid Elhussain Omdurman Islamic University, Faculty of Medical laboratory sciences, Sudan - Omdurman Ahlia University, Faulty of Medicine, Sudan-
Babiker Ahmed Mohammed Karary University Faculty of Medical laboratory sciences, Sudan
Doaa Abdullah Gasim International University of Africa, Sudan
Elyasaa Ahmed Gubartalla Ali Institute of Endemic Diseases (IEND) Khartoum University, Sudan
Manal Mohammed Khalid Elhussien Al-Mughtaribeen University, Faulty of Medicine, Sudan
Nora Nahal Bouderba University Tahri Mohammed, Faculty of Sciences of Nature and Life, Biology Department, Bechar, Algeria
Mohammed Babiker Omer Al-Neelain University, Faculty of Medical Laboratory Science, Sudan

DOI: https://doi.org/10.52981/smlj.v10i1.2768

Keywords: IDA anemia, ACD, Serum iron, ferritin, total iron binding capacity, TIBC, Transferrin saturation, Rhematoid arthritis

Abstract

Background Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by the
involvement of numerous joints and by systemic symptoms, which leads to disability and premature
death, Anemia is the most often hematological manifestation issue that occurs in RA.
Objective: This study aimed to evaluate CBC and to assess iron deficiency in RA Sudanese patients in
Khartoum state.
Material and methods: This retrospective observational study was conducted on 63 RA patients and 63
healthy individuals as control between 2018 and 2021. The CBC and iron profile (serum ferritin, serum
iron and total iron binding capacity) were carried out, the Transferrin saturation (TS) was calculated using
the formula: TS (%) = [serum iron (ug/dl)/serum transferring (mg/dl)] (Theodoros Eleftheriadis, et al.
2010)
Result: In anemic RA patients the MCV, MCH levels, serum iron, serum Ferritin, and TS% were
significant decrease while there was a significant increase in platelets count compared to control.
Conclusion: Iron deficiency is common (77%) of anemic RA patients while there was (22%) of ACD.
RA patients had lower serum iron, lower ferritin and lower TS%, while there was increase in platelets
count, Decreased hemoglobin was the strongest determinants of iron deficiency.

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