Assessment of Procalcitonin (PCT) Level among Type-2 Diabetic Mellitus with septic foot

Mohammad A S Mohammad; Alradia M A; Amaar M  Ismail; Abdelsamee Elobied Mohamed  Elamin; Ahmed Mahdi  Fadallah

doi:10.52981/smlj.v12i1.3131

Mohammad A S Mohammad Department of clinical chemistry, faculty of medical laboratory sciences, Sudan international university -Sudan
Alradia M A Department of clinical chemistry, faculty of medical laboratory sciences, Sudan international university -Sudan
Amaar M Ismail Department of biochemistry, faculty of sciences and technology, Neelen University - Sudan.
Abdelsamee Elobied Mohamed Elamin Department of clinical chemistry, faculty of medical laboratory sciences, Omdurman Islamic University –Sudan
Ahmed Mahdi Fadallah Department of clinical chemistry, faculty of medical laboratory sciences, Omdurman Islamic University –Sudan

DOI: https://doi.org/10.52981/smlj.v12i1.3131

Keywords: PCT, septic foot, type-2 DM, obese, Sudan

Abstract

Introduction: Procalcitonin (PCT) is marker of inflammatory response, stimulated by bacteria products
endotoxins and cytokines [IL.1, IL.2, IL.6 and TNF alpha].
Aim: to assess PCT level and to investigate diagnostic value as an early marker for septic foot among
type 2 DM.
Material and Methods: In cross-sectional hospital based study (n 40) septic food patients (age ranged
from 41 to 78 years old) and (n 40) DM without septic foot as control group were enrolled. Specimen
were collected from Zeenam Specialized center, Khartoum State during the period from June to July
2017. Serum PCT levels were measured using ICROMA® instrument.
Results: Analyses of frequency showed that, septic food was common in female 58% than male 42%,
while the majority are obese 70% followed by 13% overweight and 17% normal weight. Moreover poor
control septic food patients account 1.5:1 fold. Comparison revealed significant increase of PCT in
diabetic septic foot when compared with control (p-value 0.000). Dotblot regression showed PCT
correlate positively with age R=0.153 P=0347, while correlated with HbA1c R=0.368, P=0.020.
Moreover, inverse correlation was observed between PCT, duration of disease and BMI (R=0.413,
P=0.008 and R=0.458, P=0.003) respectively.
Conclusions: The data that, septic food is common in obese DM Sudanese female. PCT is significantly
higher in DM septic food patients. Thus could be useful an early diagnostic marker for septic food.

References

1. Tietz textbook of clinical and molecular diagnostics. Carbohydrates, 1986, 25, 837-864.
2. Meisner M, T Schakowsky K, palmers T, Schmid t J.] Comparison of procalcitonin and Creactive protein plasma concentration at deferent SOFA source during the course of sepsis andMODS .1994; 3 [1] 45-50.
3. Fassil W, Gemechu M D. Diabetic foot infections. American family physician, 2013;88(3):177-184.
4. Akpan U P, John OI, Daniel E N. gender and age specific prevalence and associated risk factor 48 14[1]:17-24.
5. Dandona p N, Wilson M F. Procalcetetonin increase after endotoxin in normal subject. Journal
of clinical endocrinology and metaboli.sm, 1998;79[6]:1605 -1608.
6. Mantfh M T, June M j.acute phase reactant ininfection .open forum infection disease, 2015; 7[2]1-5.
7. Agbogli H K, Annan R, Agyeman M Mensah E E. Prevalence and Risk Factors of Diabetes Mellitus Among the Inhabitants of Kumasi Metropolis , Journal of Clinical Diabetes Research,2017;1[1] 1-5.
8. Fundamental of clinical chemistry .carbohydrate, 2008; 7, 373-381.
9. William J J, Jeffcott M R, Prof K G.Diabtic foot ulcer. ScenceDirect, 2003; 361[9386]:1545-1551.
10. Charalampos P, Jean L V .sepsis biomarker .critical care biomed center, 2012; 31[37],1-19.
11. Nematollah J J, Mahdi S F, Amin S M. can procalctonin be an accurate diagnostic marker for the classification of diabetic foot ulcer .international journal of endocrinology and metabolism,2013;12[1]:e13376.
12. Karzai W M, Oberhoffer M J, Meier H A, anew indicator of systematic response to sever infection, critical care biomed center, 2016; 3 [1] 45-55.
13. Lady H J, S S K .managing hyperglycemia in diabetic foot .diabetic management, 2016; 4 [3]1-5.