The Mannich Reaction view Article Medicinal Uses of Mannich Bases
Abstract
The Mannich Reaction is used in the synthesis of natural products and pharmaceuticals. Therefore in this review we discuss the medicinal uses of Mannich bases with examples in the medicinal field. A large number of different bioactivities of Mannich bases are anticonvulsant, antimalarial, anticancer, analgesic and antimicrobial drugs. Also Mannich bases are used as prodrugs.
Application
The Mannich reaction is one of the most important C-C bond formation methods in organic synthesis (Sharifi, et. al , 2001). The Mannich-reaction is employed in the organic synthesis of natural compounds like, for instance, peptides, nucleotides, antibiotics and alkaloids. Other application are in agrochemicals such as plant growth regulators, paint and other polymer chemistry, catalysts and crosslinking and is used in the synthesis of medicinal compounds (Dimmock, 1997).
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