High Sensitive C-reactive protein as Prognostic Marker for Cardiovascular Disease among Sudanese Hypertensive Patients
Abstract
Background: Highly sensitive C-reactive protein, hs-CRP, is an acute phase protein which represents a sensitive systemic marker of inflammation and tissue damage especially in cardiovascular disease. Hypertension is a common health problem throughout the world and one of the major risk factors for Cardiovascular Disease, CVD, therefore this study aims at the evaluation of this highly sensitive C-reactive protein, hs-CRP, as a prognostic marker for CVD in hypertensive patients.
Materials and Methods: A case control study was carried out in Abuda center during the period from January to February 2016. In this study 50 hypertensive patients were enrolled (13 males and 37 females) and 50 normotensive as a control group. Serum hs-CRP levels, TG and cholesterol were measured by Cobas, 311 automated analyzer. The data were, then, analyzed by using SPSS® software computer program.
Results: The mean serum level of hs-CRP, cholesterol and triglyceride showed a significant increase in hypertensive patients compared to the control groups, assuming p-values of (0.002, 0.000 and 0.000) respectively. In case of the gender, age, BMI and duration of disease categories, the results indicated an insignificant increase in hs-CRP among females, overweight subjects and those of more than 5 years duration of HTN, with p-values of (0.382, 0.387and 0.166), respectively. Females, overweight group, more than 60 years and more than 5 years duration of HTN showed insignificant increase in diastolic and systolic BP. The mean TG level showed insignificant increase in males, normal weight group and more than a 5 year duration of HTN with p-values of (0.862, 0.509 and 0.921), respectively, and insignificant decrease in patients more than 60 years with a p-value of (0.959).
Conclusion: the study concluded that the hypertensive patients have increased hs-CRP, cholesterol and triglyceride compared to control HTN group with p-values of (0.862, 0.509 and 0.921), respectively, and an insignificant decrease in patients more than 60 years with a p-value of (0.959).
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