Screening of Hepatitis C Virus among Blood Donors in the Central Blood Bank, Wad Medani Teaching Hospital - Gezira State, Sudan
Abstract
Hepatitis C virus (HCV) infection is a major worldwide public health problem. The World Health Organization (WHO) estimates that 3% of the world's populations are chronically infected with HCV, most of these cases occur in Africa. The main objective of this study was to determine the prevalence Hepatitis C Viruses among blood donors attending to the Central Blood Bank in Wad Medani Teaching Hospital. This study was conducted during the period from 2012-2015. One thousand blood samples were collected. The mean age of the subjects was 28 1± 6.2 with a range between 18 and 49 years of age. When the selected subjects were screened for HCV by ELISA, only 2/1000 (0.2%) tested positive. This study concludes that the prevalence rate of HCV among blood donors in Wad Medani Blood Bank is 0.2%. Vaccination of HCV for the negative blood donors in is thence recommended.
References
2. Lindenbach, B. D. and C. M. Rice. "Unravelling hepatitis C virus replication from genome to function." Nature"2005;436(7053): 933-8.
3. Naoumov, N. V. "Hepatitis C virus infection in Eastern Europe." J Hepatol31 Suppl"1999; 1: 84-7.
4. Consensus conference. Treatment of hepatitis C." Gastroenterol Clin Biol26" 2002;Spec No 2 .B303-20.
5. Mudawi, H. M., H. M. Smith. "Prevalence and common genotypes of HCV infection in Sudanese patients with hepatosplenic schistosomiasis." J Med Virol"2007;79(9): 1322-4.
6. DE Sanjose, S., Y. Benavente“Hepatitis C and Non-Hodgkin Lymphoma among 4784 Cases and 6269 Controls from the International Lymphoma Epidemiology Consortium." Clin Gastroenterol Hepatol" 2008 ; 6(4): 451-8.
7. Marcellin, P., F. Pequignot "Mortality related to chronic hepatitis B and chronic hepatitis C in France: evidence for the role of HIV coinfection and alcohol consumption." J Hepatol"2008;48(2): 200-7.
8. Van Damme, P. and A. Vellinga. "Epidemiology of hepatitis B and C in Europe." Acta Gastroenterol Belg"1998; 61 (2): 175-82.
9. Mudawi, H. M., H. M. Smith, "Epidemiology of HCV infection in Gezira state of central Sudan." J Med Virol"2007;79(4): 383-5.
10. Abou, M. A. and Eltahir, Y. M. Seropositivity of hepatitis B virus and hepatitis C virus dual infection among blood donors in Nyala teaching hospital. "Virol. J." 2009; 6: 227-226.