The Predictive Values of Lymphocytopenia in West Darfur Patients with Malaria
الملخص
Background: In Sudan malaria is most commonly caused by infection with plasmodium falciparum, although by p.vivax. Malaria causes the most dangerous and highest rates of complication and mortality. Most malaria cases in 2018 were reported by the world health organization (WHO) in the African region(213 million cases of malaria or 93% of all malaria cases in the world and 70% is 5 years or younger).
Objectives: The aim of this study was to measure and compare the mean of absolute lymphocyte count in malaria patients and control groups, and to determine positive and negative predictive values of lymphocytopenia in malaria patients.
Methods: It was conducted on 100 subjects with malaria as cases and 100 subjects without malaria as controls, at EL Genina Hospital after obtaining the ethical approval and the subjects' consent. It was done by testing the CBC, differential counts, and absolute lymphocyte count then determining the means and p-values. The positive and negative predictive values were also determined.
Results: It was found that the mean of TWBC count in the case group was(7,13109/l), and (7,84109/l)in the control group, the p-value was (0.150). The mean of lymphocytes differential in the case group was (20.73%)and (33.96%)in the control group, the the p-value was (0.000). While the mean of the absolute lymphocytes counts in the the case group was (1.39109/l), it was (2.56109/l)in the control group, with a p-value (0.000). This p-value indicated that there was significant lymphocytopenia in malaria patients. The positive predictive value was 83% and the negative predictive value was 69%.
Conclusion: This study concluded that there was no significant lymphocytopenia in malaria patients and that lymphocytopenia cannot be used as the key hematological indicator of malaria infection.
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