Isolation, Investigation and Antimicrobial activity of a dihydrochalcone from the leaves of the Catharanthus roseus L.

Fath Elrahman Ahmed*1; M. Abdel Karim2

doi:10.52981/ojps.v2i3.2868

Fath Elrahman Ahmed*1 Omdurman Islamic University, Faculty of Education, Department of Chemistry and Biology
M. Abdel Karim2 Sudan University of Science and Technology, Faculty of Science, Department of Chemistry

DOI: https://doi.org/10.52981/ojps.v2i3.2868

الملخص

Dihyrochalcone is subclass of Flavonoids which are polyphenolic compounds that are widely found in the plant kingdom as secondary metabolites, they possess a variety of biological activities. The purpose of this study was to isolate and identify the Flavonoids from the leaves of Catharanthus roseus and testing it for anti-microbial activity. The plant was collected from Omdurman area, the powder was prepared from leaves and some chromatographic methods were applied to isolate compound I. The structures of this compound was elucidated based on spectroscopic methods as: IR,UV,MS and ¹HNMR spectroscopy, and also the microbial activity of Compound 1 gave activity against all organisms that were tested. The results of this study have provided scientific validity for use of this plant in traditional medicine to treat infectious diseases.