Clinical Hypoglycemic Effects of Allium cepa (Red Onion) in Type 1 Diabetic Patients

  • Imad M. Taj Eldin University of Gezira
  • Elhadi M. Ahmed University of Gezira,
  • Abd Elwahab HM National Center for Research
Keywords: Allium cepa, hypoglycemia, type 1 diabetes

Abstract

Background: Type 1 diabetes mellitus is an autoimmune disease caused by destruction of pancreatic islet beta cells and characterized by defect in insulin secretion.

Objectives: The present study was carried out to investigate the hypoglycemic effects of Allium cepa in patients with type 1 diabetic patients.

Results: In the assessment of the hypoglycaemic activity of Allium cepa in type 1 diabetic patients (n=21), crude Allium cepa (100g) caused a  considerably lowered value in the fasting blood glucose levels by about 89 mg/dl in relation to insulin (145 mg/dl) after 4 hours. Also the ingestion of crude Allium cepa by type 1 diabetic patients produced a significant reduction in the induced hyperglycemia (GTT) by about 120 mg/dl in relation to water (77 mg/dl) and the standard drug insulin (153 mg/dl).

Conclusion: Crude Allium cepa produced hypoglycemic effects, thus it could be used as a dietary supplement in management of diabetes

References

1.American Diabetes Association. Reports of theExperts Committee on the Diagnosis and Classificationof Diabetes Mellitus. Diabetes Care 2001; 23:S4-S19.
2. American Diabetes Association. Hyperglycemiccrises in patients with diabetes mellitus. Diabetic Care2001; 24: S83-S90
3. Reaven, E.; Wright, D.; Mondon, C. E et al. Effectof age and diet on insulin secretion and insulin actionin rat. Diabetes 1983; 32: 175-180.
4. Banerjee, S. K. and Maulik, S. K. Effects ofgarlicon cardiovscualr disorders: a review. NutritionalJournal 2002;1 (4): 1-14
5. Griffiths, G; Trueman, L; Crowther, T. et al. Onions:a global benefit to health. Phytotherapy Research2002; 17 (7): 603-615.
6. Augusti, KT . Therapeutic values of onion (Alliumcepa L.) and garlic (Allium sativum L.). Indian Journalof Experimental Biology 1996;34: 634-640.
7. Sharma, KK. Antihyperglycemic effects of onion:Effect on fasting blood sugar and inducedhyperglycemia in man. Indian journal of medicalresearch 1977; 65:422–429.
8. Jain, RC; Vyas, CR and Mahatma, OP.Hypoglycaemic action of onion and garlic. Lancet1973; ii:1491.
9. Jain, RC and Vyas, CR (). Onion and garlic inatherosclerotic heart disease. Medikon 1977; 6:12–14.
10. Roman-Ramos, R; Flores-Saenz, JL; Partida-Hernandez, G et al. Experimental study of thehypoglycemic effect of some anti-diabetic plants.Archivos de investigation Medica 1991;22: 87-93.
11. Schepartz, B. Regulation of Amino AcidMetabolism in Mammals. Clinical chemistry 1973; 20(3): 405.
Published
2021-08-18
Section
Original Articles