Diagnosis of Breast Cancer: is there any protocol which is applicable worldwide?
Keywords:
FNAC,, breast cancer.
Abstract
Objectives: to study the accuracy of cytopathology and to evaluate it as diagnostic pathological tool
in breast diseases.
Method: a prospective study in the period between Jan 2006 and Feb 2008. Data were analysed
using the SPSS. Sensitivity, specificity and accuracy were calculated and compared to literature.
Results: Total number of reports was 542, 271 for each cytopathology and histopathology. The
overall mean age was 41.0+ 15.3 (ranging between 14- 80) years.
The overall sensitivity, specificity and accuracy of cytopathology were 56.1, 80.9 and 63.8%
respectively while those of histopathology were 93.5, 83.5 and 89.7% respectively.
Conclusion: FNAC has low sensitivity, specificity and accuracy.
References
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19. Daltrey I, Lewis C, McKee G et al. The effectof needle gauge and local anaesthetic on thediagnostic accuracy of breast fine-needleaspiration cytology1, 2. Eur J Surg Oncol1999; 25(1): 30-33
20. Alkuwari E, Auger M. Accuracy of fineneedleaspiration cytology of axillary lymphnodes in breast cancer patients: a study of 115cases with cytologic-histologic correlation.Cancer 2008; 114(2): 89-93
21. Yong W S, Chia K H, Poh W T et al. Acomparison of trucut biopsy with fine needleaspiration cytology in the diagnosis of breastcancer. Sigapore Med J 1999; 40(9): 587-9.
2. Litherland J C. Should fine needle aspirationcytology in breast assessment be abandoned?.Clin Radiol 2002; 57(2): 81-4
3. Morris K T, Pommier R F, Morris A et al.Usefulness of the triple test score for palpablebreast masses. Arch Surg 2001;136(9):1008-13
4. Green B, Dowley A, Turnbull L S et al.Impact of fine-needle aspiration cytology,ultrasonography and mammography on openbiopsy rate in patients with benign breastdisease. Br J Surg 1995; 82(11): 1509-11
5. El Tahir A, Jibril J A, Squair J et al. Theaccuracy of “one-stop” diagnosis for 1 110patients presenting to a symptomatic breastclinic. J R Coll Surg Edinb 1999; 44(4): 226-30
6. Daltrey I R, Kissin M W. Randomized clinicaltrial of the effect of needle gauge and localanaesthetic on the pain of breast fine-needleaspiration cytology.Br J Surg 2000; 87(6):777-9
7. Roskell D E, Buley I D. Fine needle aspirationcytology in cancer diagnosis. Is quick, cheapand accurate when used appropriately. BMJ2004; 329: 244-245
8. Denley H, Pinder S E, Elson C W et al.Preoperative assessment of prognostic factorsin breast cancer. J Clin Pathol 2001; 54:20-24
9. Hiregoudar Abhijit D, Godhi Ashok S, MalurPrakash R et al. Accuracy of intra-operativeimprint smears in breast tumours: A study of40 cases with review of literature. IndianJournal of Surgery 2006; 68(6) 302-5
10. Motomura K, Inaji H, Komoike Y et al.Intraoperative sentinel lymph nodeexamination by imprint cytology and frozensectioning during surgery. Br J Surg 2000;87(5): 597-601
11. Nasseem Husain O A, Butler E B.Cytopathology in the United Kingdom: 1854to the present. Diagn Cytopathol 2000; 22(3):203-6
12. Minkowitz S, Moskowitz R, Khafit R Aet al.Tru-cut needle biopsy of the breast. Ananalysis of its specifity and sensitivity. Cancer1986; 57(2): 320-3
13. Scopa C D, Koukouras D, Spiliotis J et al.Comparison of fine needle aspiration and Trucutbiopsy of palpable mammary lesions.Cancer detection and prevention 1996; 20(6):620-4
14. Annual Criminal Report: Annual report ofcrimes of the Sudan issued by the ministry ofinterior . Khartoum: Sudan Currency PrintingPress; 1999. p 143
15. Lynch J B, Hassan A N M, Omar A. Cancer inthe Sudan. S.M.J. 1963; 2(2): 29-37
16. Feicher G E, Haberthϋr F, Gobat S et al..Breast cytology: Statistical analysis andcytohistologic correlations. Acta Cytologica1997; 41(2): 327-332
17. Tohnosu N, Kobayashi Y, Nasume T et al.US-guided mammotome biopsy of breastmasses in comparison with US-guidedaspiration biopsy cytology. In: Ueno E,Shiina T, Kuboto M, Sawai K, Research anddevelopment in breast ultrasound. Tokyo:Springer; 2005. pp 181-4
18. Akçil M, Karaağaoğlu E, Demirhan B.Diagnostic accuracy of fine-needle aspirationcytology of palpable breast masses: An SROCcurve with fixed and random effects linearmeta-regression models. Diagn cytopathol2008; 36(5): 303-310
19. Daltrey I, Lewis C, McKee G et al. The effectof needle gauge and local anaesthetic on thediagnostic accuracy of breast fine-needleaspiration cytology1, 2. Eur J Surg Oncol1999; 25(1): 30-33
20. Alkuwari E, Auger M. Accuracy of fineneedleaspiration cytology of axillary lymphnodes in breast cancer patients: a study of 115cases with cytologic-histologic correlation.Cancer 2008; 114(2): 89-93
21. Yong W S, Chia K H, Poh W T et al. Acomparison of trucut biopsy with fine needleaspiration cytology in the diagnosis of breastcancer. Sigapore Med J 1999; 40(9): 587-9.
