Article Neurotransmitters – A biochemical view
Keywords:
Neurotransmitter,, Synaptic vesicles, Acetylcholine (ACh), Aminobutyrate (GABA), Myasthenia Gravis (MG), Parkinson's disease, Opioid peptides
Abstract
The neurotransmission at most if not all synapses is chemical and is of great biochemical, physiological and pharmacological importance. Neurons communicate with each other at synapses by a process called synaptic transmission in which the release of small quantities of chemical
messengers, called neurotransmitters that alter the electrical activity of neurons after they interact with receptors on post-synaptic cell surfaces. This review gives a biochemical view on the nature of neurotransmitters and presents the biochemical chart and the medical relevance of the most
important neurotransmitters.
References
1. Schousboe A. and Waagepetersen H S. GABA:Homeostatic and pharmacological aspects. Progress inbrain research. Gaba and the Basal Ganglia - FromMolecules to Systems. 2007; 160: 9-19.
2. Greengard P, Valtorta F, Czernik AJ et al. Synapticvesicle phosphoproteins and regulation of synapticfunction. Science AAAS. 1993; 259(5096): 780-785
3. Bajjalieh S M. and Scheller R H. The Biochemistryof Neurotransmitter Secretion. Jbc online by TheAmerican Society for Biochemistry and MolecularBiology. 1995; 270(5): 1971-74.
4. Vijayan E. Role of neurotransmitters andneuropeptides in the control of gonadotropin release: Areview. Journal of biosciences. 1985;7(2): 207-213.
5. Hyman S. E. Neurotransmitters. Current biology.2005; 15(5): R154-R158.
6. Murray R K, Granner D K, Mayes P A et al.Harper's Illustrated Biochemistry. 26th edition. LangeMedical Books/McGraw-Hill; 2003.
7. Petroff OA. "GABA and glutamate in the humanbrain". Neuroscientist 2002; 8 (6): 562–73.
8. Schousboe A, Waagepetersen H S. "GABA:homeostatic and pharmacological aspects". Prog. BrainRes. 2007; 160: 9–19.
9. Taylor C., Fricker A. D., Devi L. A et al.Mechanisms of action of antidepressants: fromneurotransmitter systems to signaling pathways.Cellular Signalling. 2005; 17(5): 549-557.
10. Boon N A, Colledge N R, Walker B R et al.Davidson's Principles and Practice of Medicine. 20thedition. Churchill Livingstone, Elsevier; 2006.
11. Lodish HF, Berk A, Kaiser CA et al. MolecularCell Biology. 6th edition. W.H. Freeman; 2007.
12. Koolman J and Roehm K H. Color Atlas ofBiochemistry. 2nd edition. Thieme; 2005
.13. Gilbert H F. Basic concepts in Biochemistry- Astudent survival guide. 2nd edition. McGraw-Hill; 2000.
14. Murray R K, Granner D K, Mayes P A, andRodwell V W. Harper's Biochemistry. 24th edition,Lange Medical Books; 1996.
15. Corwin E. J. Handbook of Pathophysiology. 3rdedition. Lippincott Williams and Wilkins; 2008.
16. Berg J M, Tymoczko J L, Stryer L. Biochemistry.5th edition. W. H. Freeman and company; 2002.
17. Ghildyal P and Manchanda R. Neurotransmissionby ATP: New insights, novel mechanisms. IndiaJournal of Biochemistry and Biophysics. 2002; 39(3):137- 47.
18. Ghildyal P, Palani D and Manchanda R. OldMolecule, New Roles: Neurotransmission by ATP.2005
19. Ganong W F. Review of medical physiology. 22ndedition. The McGraw-Hill Companies; 2005.
20. Humeau Y, Doussau F, Grant N J et al. Howbotulinum and tetanus neurotoxins blockneurotransmitter release. Biochimie. 2000; 82(5): 427-446.
21. Gottfries C G. Alzheimer's disease and seniledementia: Biochemical characteristics and aspects oftreatment. Psychopharmacology, 1985; 86: 245-252).
22. Abi-Dargham A, Rodenhiser J, Printz D et al.From the cover: increased baseline occupancy of D2receptors by dopamine in schizophrenia. Proc NatlAcad Sci U S A. 2000;97(14):8104-9.
23. Manso G. Biochemistry of neurotransmitters.2008(The Whole Health Center • 7211 Regency SquareBlvd, Suite 200 • Houston.
24. Haines D E. Fundamental neuroscience for basicand clinical applications. 3rd edition. Elsevier; 2007.
2. Greengard P, Valtorta F, Czernik AJ et al. Synapticvesicle phosphoproteins and regulation of synapticfunction. Science AAAS. 1993; 259(5096): 780-785
3. Bajjalieh S M. and Scheller R H. The Biochemistryof Neurotransmitter Secretion. Jbc online by TheAmerican Society for Biochemistry and MolecularBiology. 1995; 270(5): 1971-74.
4. Vijayan E. Role of neurotransmitters andneuropeptides in the control of gonadotropin release: Areview. Journal of biosciences. 1985;7(2): 207-213.
5. Hyman S. E. Neurotransmitters. Current biology.2005; 15(5): R154-R158.
6. Murray R K, Granner D K, Mayes P A et al.Harper's Illustrated Biochemistry. 26th edition. LangeMedical Books/McGraw-Hill; 2003.
7. Petroff OA. "GABA and glutamate in the humanbrain". Neuroscientist 2002; 8 (6): 562–73.
8. Schousboe A, Waagepetersen H S. "GABA:homeostatic and pharmacological aspects". Prog. BrainRes. 2007; 160: 9–19.
9. Taylor C., Fricker A. D., Devi L. A et al.Mechanisms of action of antidepressants: fromneurotransmitter systems to signaling pathways.Cellular Signalling. 2005; 17(5): 549-557.
10. Boon N A, Colledge N R, Walker B R et al.Davidson's Principles and Practice of Medicine. 20thedition. Churchill Livingstone, Elsevier; 2006.
11. Lodish HF, Berk A, Kaiser CA et al. MolecularCell Biology. 6th edition. W.H. Freeman; 2007.
12. Koolman J and Roehm K H. Color Atlas ofBiochemistry. 2nd edition. Thieme; 2005
.13. Gilbert H F. Basic concepts in Biochemistry- Astudent survival guide. 2nd edition. McGraw-Hill; 2000.
14. Murray R K, Granner D K, Mayes P A, andRodwell V W. Harper's Biochemistry. 24th edition,Lange Medical Books; 1996.
15. Corwin E. J. Handbook of Pathophysiology. 3rdedition. Lippincott Williams and Wilkins; 2008.
16. Berg J M, Tymoczko J L, Stryer L. Biochemistry.5th edition. W. H. Freeman and company; 2002.
17. Ghildyal P and Manchanda R. Neurotransmissionby ATP: New insights, novel mechanisms. IndiaJournal of Biochemistry and Biophysics. 2002; 39(3):137- 47.
18. Ghildyal P, Palani D and Manchanda R. OldMolecule, New Roles: Neurotransmission by ATP.2005
19. Ganong W F. Review of medical physiology. 22ndedition. The McGraw-Hill Companies; 2005.
20. Humeau Y, Doussau F, Grant N J et al. Howbotulinum and tetanus neurotoxins blockneurotransmitter release. Biochimie. 2000; 82(5): 427-446.
21. Gottfries C G. Alzheimer's disease and seniledementia: Biochemical characteristics and aspects oftreatment. Psychopharmacology, 1985; 86: 245-252).
22. Abi-Dargham A, Rodenhiser J, Printz D et al.From the cover: increased baseline occupancy of D2receptors by dopamine in schizophrenia. Proc NatlAcad Sci U S A. 2000;97(14):8104-9.
23. Manso G. Biochemistry of neurotransmitters.2008(The Whole Health Center • 7211 Regency SquareBlvd, Suite 200 • Houston.
24. Haines D E. Fundamental neuroscience for basicand clinical applications. 3rd edition. Elsevier; 2007.
