Possibility of Xanthine Oxidase and Malondialdehyde as a marker for Myocardial Infarction

Abdelhamid MA; Salim BI; Abdelsalam KA

doi:10.52981/sjms.v6i2.1447

Abdelhamid MA Department of Biochemistry, U of K, Sudan
Salim BI Department of Laboratory, Sudanese Armed Forces Hospital - Omdurman
Abdelsalam KA Faculty of Medical Laboratory Sciences OIU.

DOI: https://doi.org/10.52981/sjms.v6i2.1447

Keywords: thiobarbituric, aspartate amino-transferase, creatine kinase, troponin

Abstract

Background: the serum markers of myocardial injury are used to help in establishing the diagnosis
of myocardial infarction.
Objective: to measure the levels of xanthine oxidase activity and malondialdehyde in myocardial
infarction patients.
Methods: 100 patients with myocardial infarction and 50 healthy persons were included in this
study. Xanthine oxidase activity assayed according to the method described by bergmeyer, h.u.
while malondialdehyde (MDA) estimation was carried by thiobarbituric acid (TBA) based
colorimetric method.
Results: significant increasing levels of xanthine oxidase activity and malondialdehyde were found
in the blood of the patients with myocardial infarction when compared to healthy persons.
Conclusions: we propose the measurement of the blood levels of xanthine oxidase as a marker of
myocardial infarction.

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