Evaluation of Serum Gonadotropin and Prolactin Level among Sudanese Patients with Chronic Renal Failure

Abstract

Background: Generally, patients on hemodialysis for chronic renal failure also have
endocrine defects and sexual function disorders. In this study, we aimed to assess the
serum prolactin (PRL), luteinizing hormone (LH) and follicle-stimulating hormone (FSH)
in patients with chronic renal failure.
Methods: This hospital-based case–control study was conducted at Jabal Aulia
Teaching Hospital, Khartoum, Sudan. The study was carried out between August 2019
and February 2020. A total of 100 subjects were enrolled – 50 chronic renal failure
patients and 50 as controls. The serum hormones were estimated using Tosoh 360.
SPSS version 25 was used to analyze the results.
Results: The serum PRL, LH, and FSH were significantly increased among chronic
renal failure patients than their healthy counterparts (p-value = 0.000). The age of
patients was positive correlated with plasma hormones, PRL (r = 0.332, p = 0.001), LH
(r = 0.387, p = 0.000), and FSH (r = 0.320, p = 0.001). No correlation was found between
the duration of the disease and serum hormones.
Conclusion: Patients with chronic renal failure had a highly significant increase of
serum PRL, LH, and FSH and also the age of the patients was positively correlated
with serum hormones.