Audit of advanced gastric cancer at Ibn Sina Hospital, Khartoum, Sudan

Khalid Alsir; Amagid M Masaad; Mohd Abdelhameid

doi:10.52981/sjms.v1i1.815

Khalid Alsir Faculty of Medicine-Omdurman Islamic University
Amagid M Masaad Faculty of Medicine-Omdurman Islamic University
Mohd Abdelhameid Faculty of Medical Lab-Omdurman Islamic University

DOI: https://doi.org/10.52981/sjms.v1i1.815

Keywords: Audit of advanced, gastric cancer, Ibn Sina Hospital

Abstract

Background: Worldwide, gastric cancer is the second most common cancer (second to lung cancer). In Sudan incidence and prevalence are not clear because of absence of National Cancer Registry.

Aim: To find out the frequency of the gastric mesenchymal tumours, whether gender and age influences the clinico-pathological features of gastric cancer and to audit the outcome of management of advanced gastric cancer at Ibn Sina Hospital.

Methods: This is a retrospective study in 139 gastric cancer patients admitted from May 1997 through November 2004. Demographic data, details of the clinical, endoscopic features of gastric cancer, as well as the operative details, and histopathology, the post-operative complication, and hospital mortality were analysed. Available data on family history of cancer; smoking and alcohol consumption was also collected.

Results: Mesenchymal tumours account for 15(10.9%) of all gastric cancer. Lymphoma alone constituted 5.8% while leiomyosarcoma constituted 4.4%. Hospital mortality rate was zero%, 2.8%, and 3.6% in distal subtotal, proximal subtotal and total gastrectomy respectively. Hospital mortality was 18 (12.9%) patients. Age and sex have no significance on the clinicopathological features of advanced gastric cancer.

Author Biographies

Khalid Alsir, Faculty of Medicine-Omdurman Islamic University

Assist. Professor

Amagid M Masaad, Faculty of Medicine-Omdurman Islamic University

Prof of Surgery

Mohd Abdelhameid, Faculty of Medical Lab-Omdurman Islamic University

Dean Faculty of Medical Lab. Sciences

References

1.Nishida T, Hirota S: Biological and clinical review of stromal tumours in the gastrointestinal tract. Histolology and Histopatholology Journal 2000; 15(4): 1293-30.
2. Miettinen M, Lasota J: Gastrointestinal stromal tumours--definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis. Virchows Archives 2001; 438(1): 1-12.
3. Berman J, O'Leary TJ: Gastrointestinal stromal tumour workshop. Human Patholology Journal 2001; 32(6): 578-82.
4. Pierie JP, Choudry U, Muzikansky A: The effect of surgery and grade on outcome of gastrointestinal stromal tumours. Archives of Surgery 2001; 136(4): 383-9.
5. Pidhorecky I, Cheney RT, Kraybill WG, et al: Gastrointestinal stromal tumours: current diagnosis, biologic behavior, and management. Annals of Surgery and Oncology 2000; 7(9): 705-12.
6. Antoniole DA, Goldman H. Changes in the location and type of gastric adenocarcinoma. Cancer 1982; 775-81.
7. Haggitt RC. Premalignant lesions of the gastrointestinal tract. View Dig Dis 1985; 1-4.
8. Nagayot. Histopathology of gastric Dysplasia. In: Filipe MI, Jass JR. First edition. Gastric carcinoma. Edinbrugh: Churchill Livingstone. 1981; 16-31.
9. Silverberg E, Boring CC, Squares TS. Cancer statistics. Canadian Cancer Journal Clinics 1990; 9-26.
10. Aoki K, Tominaga S, Kuroishi T. Age adjusted death rates for cancer by site in 50 countries in 1975. Japan Journal of Cancer Research 1981; 2251-74.
11. Su-Shun Lo, Hsu-Sung Kuo, Chew-Wun Wu, et al. Poorer prognosis in young patients with gastric cancer. Hepato-gastroentrology1999; 46: 2690-93.
12. Isozaki H, Fujii K, Nomura E, et al. Prognostic factors of advanced gastric carcinoma 58 without serosal in vasion (p T2 gastric carcinoma).Hepato-gastroentrology1999; 46: 2669-72.
13. Wansik Yu , Kim HS, Choi GS , et al. Perigastric lymph nodes with metastasis in gastric cancer. Hepato-gastroentrology1999; 46: 2658-61.
14. Piso P, Meyer HJ, Edris C,et al . Surgical therapy of gastric stump carcinoma- a retrospective analysis of 109 patients. Hepato-gastroentrology1999; 46: 2643- 47.
15. Nakata Y, Ki mura K, Tomioka N, et al . Gastric exclusion for unresectable gastric cancer. Hepato-gastroentrology1999; 46: 2654-57.
16. Fuchs CS, Mayer RJ. Gastric carcinoma. New Engl J Med 1995; 333: 32-41.
17. Craanen ME , Dekker W, Blok P,et al. Time trends in gastric carcinoma: changing pattern type and location. Am J Gastroenterol 1992;87:572-9.
18. Blot WJ, De vesa SS, Kneller RW , et al. Rising in cidence of adenocarcinoma of the esophagus an d gastric cardia. JAMA1991;265:1287-9.
19. Ekstrom AM, Serafini M, Nyren O, et al.Dictary antioxidant in take and the risk of cardia cancer and no cardia cancer of the intestinal and diffuse types: a population-based case-control study in Sweden. Int J Cancer 2000; 87(1):133-40.
20. Roukos DH. Current status and future perspectives in gastric cancer management. Cancer Treat Rev. 2000 ;26(4):243-55.
21. Lauren PA , Nevalainen JT. Epidemiology of intestinal and diffuse types of gastric carcinoma: a new-trend study in Finland with comparison between studies from high- and low-risk areas. Cancer 1993;71:2926-33
22. Munoz N, Connelly R. Ti m e trends of intestinal and diffuse types of gastric cancer in the United States. Int J Cancer 1971;8: 158-64.
23. Ekstrom AM, Hansson LE, Signorello LB,et al. Decreasing incidence of both major histologic subtypes of gastric adenocarcinoma--a population-based study in Sweden. Br J Cancer 2000 Aug; 83(3):391-6.
24. Bloss RS, Miller TA, Copeland E. Carcinoma of the stomach in the young adults. Surg Gyne Obstet 1980; 150:883- 886.
25. Tamura PY, Curtiss C. Carcinoma of th e stomach in the young adults. Cancer 1960; 13:379- 385.
26. Mately PJ, Dent DM, Madden MV , et al. Gastric carcinoma in young adults. Ann Surg 1988; 208: 593-596.
27. GrabiecJ, Owen DA. Carcinoma of the stomach in young persons. Cancer 1985; 56: 388-396.