Echocardiography in helping to determine the causes of pericardial effusion in the Sudanese patients
Abstract
Pericardial disease is not uncommon in Sudan and the etiology may impose a diagnostic problem. The aim of this study is to determine the etiology of isolated pericardial effusion and to assess the usefulness of the echocardiographic features of the effusion in helping to determine the etiology.
Patients and Methods:This is an observational cross-sectional prospective study done from Jan. 2002 to Aug. 2003. Fifty one patients were collected from four centers in Khartoum State. Chest X-ray, Echocardiogram and
ECG were done for all patients. Pericardiocentesis was done for 35 patients [68.6%]. Specific investigations for the etiological diagnosis were done when appropriate.
Results and Conclusion: Male to female ratio was 1.3:1.The age ranged between 4 and 80 years with 68% of patients in the age group 11-40 years. Forty one Patients [82%] were referred with a correct diagnosis of pericardial effusion. The etiology was evident clinically or by specific investigation in 31 patients [61%] and 20 patients [39%] needed pericardiocentesis. The common etiologies were tuberculosis, malignancies, rheumatological, idiopathic and bacterial infection consecutively. The result showed useful echo features to differentiate between tuberculous, occult malignancy and idiopathic etiologies. Thickened Effusion, fibrin strands and shaggy pericardium are suggestive of tuberculosis while thickened Effusion without fibrin strands or shaggy pericardium makes malignancy a competitive diagnosis and the thin appearance of the effusion with shaggy pericardium and no fibrin strands goes more with idiopathic effusion while the features of massive
effusion, tamponade or the hemorrhagic appearance of the fluid although common in these three etiologies has no much differential value.
References
2. Goldberger E. Diseases of the pericardium. In: Essentials of Clinical Cardiology.1st ed. Philadelphia: Lippincott Company; 1990. p. 312 – 324.
3. Hampton JR. Infective endocarditis and other infection. In: Integrated Clinical Science: Cardiovascular Disease. London: William Heinemamm Medical Books; 1985.p. 246 – 247.
4. Guyton CA. The body fluid and kidneys .In: Textbook of Medical Physiology.6th ed. Philadelphia: W.B, Saunders company; 1981.p.339.
5. Kumar v, Cotran RS, Robbins L. The heart. In: Robbins' Basic Pathology. 7th ed. Philadelphia; W.B. Saunders; 2003.p. 393 – 394.
6. Williams PL, Warwick R. Angiology. In: Gray's Anatomy. 36thed. Edinburgh : Churchill Livingstone ;1986.p. 634 – 635 .
7. Underwood JCE. Cardiovascular System. In : General and systemic Pathology. 2nd ed. Edinburgh : Churchill Livingstone; 1997. p. 651 – 352.
8. Armstrong P, Wastie ML . Cardiovascular System. In : Diagnostic Imaging .4th ed. Oxford : Blackwell Science Ltd; 1998. p. 116 – 118.
9. Marinella MA . Electrocardiographic Manifestation and Differential Diagnosis of Acute Pericarditis. www.aafp.org/afp/980215 ap/marinell.html.
10. Goldman MJ. Miscellaneous Abnormal Electrocardiographic pattern. In : Principles of clinical Electrocardiography. Los Angelos; Lange Medical Publication; 1986.P. 300 – 397.
11. Fouci AS , Braunwald E, Isselbacher KJ et al. Pericardial Disease In . Harrison's Principles of Internal Medicine. 14th Ed. New York : McGraw Hill Health Professions Division ; 1998 . p. 1334 – 1341.
12. Blaivas M. Incidence of Pericardial Effusion in Patients Presenting to the Emergency Department with Unexplained Dyspnoea. Academic Emergency medicine 2001 ; 8: 1143-1146.
13. Fernandes F , Ianni BM , Arteaga E et al. Value of pericardial biopsy in the etiologic diagnosis of pericardial diseases . Arq Bras Cardio 1998 ; 70: 393 –395.
14. ChiaBL, Choo M, Tan A, et al.Echocardiographic abnormalities in tuberculous pericardial effusion. Am Heart J 1984;107:1034-5.[Medline]
15. Liu PY, Li yh, Tsai WC, et al, Usefulness of intrapericardial abnormalities in the diagnosis of tuberculous pericardial effusion. Am J Cardiol 2001;87:1133-5. [Cross Ref] [Medline].
16. Aghababian RV. Pericardial Diseases. In : Emergency Management of Cardiovascular Disease. 1sted. Boston: Butterworth Heinemann ; 1994. p. 217 –238.
17. Millair A, Wurtz A , de Groote P et al Malignant pericardial effusion: usefulness of pericardioscopy. Am Heart J 1992; 124: 1030 – 1034.
18. Oh KY , Shimizcc M, Edwards WD et al. Surgical pathology of the parietal pericardium : a study of 344 Cases ( 1993 – 1999). Cardio Vasc Pathol 2001 ; 10: 157-68
19. Merce J, Sagrista-Sauleda J, Permanyer – Miralda G, et al. Pericardial effusion in the elderly: A different disease ?. Rev Esp cardiol 2000; 53: 1432-1436.
20. Tsang TS, Barnes ME , Gersh BJ et al. Outcomes of clinically significant idiopathic pericardial effusion requiring intervention. Am J Cardiol 2003; 91: 704-707.
21. Campione A, Cacchiavelli M, Ghiribelli C et al. Which treatment in pericardial effusion? J cardio Vasc Surg (Torino) 2002 ; 43: 735-739.
22. Vithalani GK . A study of 40 cases of pericardial effusion. Indian Journal of Tuberculosis 1992; 39: 128 – 129.
23. Cheema MA , Gholib MB , Shatoor AS et al. Pattern of Pericardial Disease in the Asir Region of Saudi Arabia.www.kfshrc.edu.da/annals/192/98-166.html.
24. Guberman BA, Fowler No, Engel PJ et al. Cardiac tamponade in medical patients. Circulation 1981; 64: 633-640.
25. Sagrista – Sauleda J, Merce J, Permanyer- Miralaa G, et al. Clinical clues to the causes of large pericardial effusions. Am J Med 2000 Aug l ; 109(2) : 95 – 101.
26. Mok GC , Menhamen S. large pericardial effusions of inflammatory origin in childhood. Cardiol Young 2003 ; 13 : 131-136.
27. Noureddine M, Bennis A, Raquim S et al. [Cardiovascular abnormalities of antiphospholipid antibody syndrome][French].Arch Mal Coeur Vaiss 2003;96:324–331.
28. Komsuoglu B, Goldeli O, Kulan K et al. Tuberculous pericarditis in north-east Turkey: An echocardidographic study. Acta Cardiol 1994; 49: 157 – 163.
29. Barakovic B, A bdovic E , et al. Echocardiography as a diagnostic method for pericardial effusion. Proceeding of the 2nd congress of cardiology and angiology of Bosnia and Herzegovina, 2001 Jun 30 –Jul 2 ; Sarajevo. Bosnia and Herzegovina .
30. Balghith M , Taylor DA , jugdutt Bl . Cardiac tamponade as the first clinical manifestation of metastatic adenocarcinoma of the lung. Can J Cardiol 2000 ; 16: 925-927.
31. El Allaf F , Buretta R , Pierard L et al. Cardiac tamponade as the first manifestation of cardiothoracic malignancy : a study of 10 cases . Eur Heart J 1986 ; 7 : 247- 253.
32. S George, A L Salama, B Uthaman et al. Echocardiography in differentiating tuberculous from chronic idiopathic pericardial effusion. Heart 2004;90:1338-1339.