Vitamin D Receptors Gene Polymorphisms among Sudanese Patients with Prostate Cancer

Abuagla M.  Dafalla; Dafalla  Abuidris; Abakar AD Abakar; Amira S.  Khalafalla; Ameer Mohamed  Dafalla; Adil  Mergani; GadAllah  Modawe; Yousif Abdelhameed  Mohammed

doi:10.52981/smlj.v10i2.2862

Abuagla M. Dafalla National Cancer Institute, University of Gezira, Wad Medani, Sudan
Dafalla Abuidris Faculty of Medical Laboratory Science, University of Gezira, Wad Medani, Sudan.
Abakar AD Abakar National Cancer Institute, University of Gezira, Wad Medani, Sudan
Amira S. Khalafalla National Cancer Institute, University of Gezira, Wad Medani, Sudan
Ameer Mohamed Dafalla Faculty of Medical Laboratory Science, University of Gezira, Wad Medani, Sudan.
Adil Mergani Faculty of Medical Laboratory Science, University of Gezira, Wad Medani, Sudan.
GadAllah Modawe Faculty of Medicine and Health Sciences, Omdurman Islamic University, Sudan.
Yousif Abdelhameed Mohammed Faculty of Medical Laboratory Science, University of Gezira, Wad Medani, Sudan.

DOI: https://doi.org/10.52981/smlj.v10i2.2862

Keywords: VDR SNPs, prostate cancer,, vitamin D receptor,, Sudan

Abstract

Background: Prostate cancer has been most frequently diagnosed cancer in men in Sudan regarding to statistics data from the National Cancer Registry. Moreover, it was the second most prevalent cancer in men globally. BsmI, TaqI, FokI, and ApaI restriction enzymes are the most extensively investigated single nucleotide polymorphisms (SNP) in VDR, respectively, they are found in exon 2 (FokI), intron 8 (ApaI and BsmI) (TaqI).

Material and method: Study attempted to investigate the vitamin D receptor gene polymorphisms in Sudanese prostate cancer patients, this case control study included eight seven subjects they were split into two groups, cases group which included 42 prostate cancer patients who were identified by histology and control group which included 45 healthy individual as control. Data were collected by questionnaire and analyzed by statistical package for social sciences version (21) and SNP stat online web-based application program.

Results: Total of 87 individuals were included; 42 as case and 45 as control with age mean and median (71.78±8.04) and (70) respectively, rs731236, rs1544410 and rs2228570 SNPs has significant association between prostate cancer risk when compared with control group, contrary to this finding rs7975232 failed to find any associated with prostate cancer, furthermore all four SNP failed to find any associated with stage, Gleason grade, age, BMI, PSA level, and vitamin D levels.

Conclusion: The study concluded that polymorphisms of VDR gene have significant association with prostate cancer except ApaI SNP.

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