Association between Inflammatory Cytokines and Liver Functions in Rheumatoid Arthritis Patients
الملخص
Background: Rheumatoid Arthritis (RA) associated with abnormal liver tests, and medications used for RA are often hepatotoxic. Therefore, this study aims to investigate an association between pro inflammatory, ant iinflammatory cytokines and liver function tests in rheumatoid arthritis patients.
Materials and Methods: In a descriptive cross-sectional study, 88 RA patients were included, 84 were females and 4 were males, age ranged from 21 to 81 years old. Serum interleukin 10 (IL-10), interleukin 17 (IL-17), Osteopontin OPN and liver function tests were measured. Results: The frequency of RA is higher among adults >41 Years 72(81.8%) than young adults ≤41 Years 16(18.2%), RA is common in females 84(95.5%) than males 4(4.5%) approximately 21:1 fold. Young adults had higher abnormal IL-10 than adults RA patients (OR = 3.72, p-value 0.044). Abnormal IL-17 (OR= 5.67, p-value 0.034) were found to be increased in young adults RA patients. No association observed between age and OPN. No association between duration of disease and IL-10, IL-17 and OPN. No association found between types of treatment and IL-10, IL-17 and OPN. No association observed between IL-10, IL-17, OPN and liver parameters (AST, ALT, ALP, ALB, TP, and GGT).Conclusion: in conclusion proinflammatory and antiinflammatory cytokines are not associated with liver functions as has been demonstrated in RA patients.
المراجع
1. Abd Elazeem I M, Mohammed A R and Abdallah H N. (2018). Correlation of serum interleukin-10 with disease activity and severity in systemic lupus erythematsus. Egyptian rheumatology and rehabilitation; 45(1): 1-9.
2. Abdelsalam S K, Hashim N T, Elsalamabi E M and Gismalla B G. (2011). Periodontal status of Rheumatoid arthritis patients in Khartoum state. Biomed central; 4:1-6.
3. Akdeniz S. Akdeniz O, Sakalli N, Gurer G, Ture M and Yesil H. (2018). The relationship between interleukin-17 and osteoporosis in patients with rheumatoid arthritis. Turk journal of osteoporos; 24: 46-52.
4. Al Zifzaf S D, Mokbel N A and Abdelaziz M D. (2015). interleukin-17 in Behcets disease: relation with clinical picture and disease activity. Egyptian rheumatology and rehabilitation; 42(2): 34-38.
5. Athanasiadous D, Jiang W, Goldbaum D, Saleem A, Basu K, Pacella S M, Böhm F C, Chromik R R, Hincke T M, Rodríguez N B A, Vali H, Wolf E S, Gray J J, Bui H K, Mckee D M. (2018). Nanostructure, osteopontin, and mechanical properties of calcitic avian eggshell. Science Advances; 4 (3219): 1-13.
6. Conway R and Carey J. (2017). Risk of liver disease in methotrexate treated patients. World J Hepatol; 9(26): 1092-1100.
7. Dinic R B, Rajkovic T S, Zivkovic V and Grgov S. (2018). Clinical connection between rheumatoid arthritis and liver damage. Rheumatology; 38:715-724.
8. Du W J, Zhen J H, Zeng Z Q, ZhengZ M, Xu Y, Qin L Y and Chen S J. (2013). Expressing of IL 17 associated with disease progression and liver fibrosis with hepatitis B virus infection: IL-17 in HBV infection. Diagnostic pathology; 8:1-7.
9. Elsedig M I, Elhag W, Elmak M J and Abbas M. (2014). Sero prevalence of human parvovirus B19 antibody among Sudanese patients with rheumatoid arthritis. American journal of ethno medicine; 1:402-407.
10. Elvira D, Nasrul E, Sofyan Y, Ecroli E D and Darwin E. (2018). Increased serum levels of interleukin-17 and transforming growth factor in patients with Graves’ disease. Earth and Environmental Science; 125: 1-4.
11. Holdsworth S R and Yi G P. (2015). Cytokines: Names and Numbers You Should Care About. Clinical Journal of the American Society of Nephrology; 10: 2243–54.
12. Iida T, Wagatsuma K, Hirayama D and Nakase H. (2018). Is Osteopontin a Friend or Foe of Cell Apoptosis in Inflammatory Gastrointestinal and Liver Diseases?. International Journal of Molecular Sciences; 19(7): 1-15.
13. Iwadate H, Kobayashi H, Kanno T, Asano T, Saito R, Sato S, Suzuki E, Watanabe H and Ohira H. (2013). Plasma Osteopontin is correlation with bone resorption marker in rheumatoid arthritis patients. International journal of rheumatic disease; 17(1).
14. Kobak S and Bes C. (2018). autumn late: geriatric rheumatoid arthritis. Therapeutic advances in musculoskeletal disease; 10(1) 3-11.
15. Kwan Ho T C, Mok CC, Cheung T T, Kwok Y K and Lung Yip M R. (2019). Management of rheumatoid arthritis. Clinical rheumatology; 38: 3331-50.
16. Luukkonen J, Pascual M L, Patlaka C, Lång P, Turunen S , Halleen J, Nousiainen T, Valkealahti M, Tuukkanen J, Andersson G R, Lehenkari P. (2017). Increased amount of phosphorylated proinflammatory osteopontin in rheumatoid arthritis synovia is associated to decreased tartrate-resistant acid phosphatase 5B/5A ratio. PLoS ONE; 12(8): 1-15.
17. Mengesha B G and Conti H R. (2017). The Role of IL-17 in Protection against Mucosal Candida Infections. Journal of Fungi; 3 (52): 1-12.
18. Mursal T, Elbager S , Fadl Elmola A, Ahmed R , Mohamed M, Abbas T. (2016). Differential diagnosis of anemia in rheumatoid arthritis Sudanese patients. World journal of pharmaceutical and medical research; 2(4): 1-4.
19. Negera E, Walker S, Bobosha K, Bekele Y, Endale B, Tarekegn A, Abebe M, Aseffa A, Dockrell H and Lockwood D N. (2018). The effect of prednisolone treatment on cytokine expression in patients with Erythema Nodosum Leprosum reaction. Frontiers immunology; 9: 1-15.
20. Noack M, Ndongo N and Miossec P. (2016). Evaluation of antiinflammatory effect of steroids and arthritis related biotherapies in an invitro coculture model with immune cells and synoviocytes. Frontiers in immunology; 7:1-10.
21. Rakuomi O, Go O, Kamau, Genga E, Okalebo F and Ogutu E. (2017). Prevalence of abnormal liver function tests in rheumatoid arthritis. African journal of rheumatology; 5(1): 70-75.
22. Shi L, Shi L, Wang X and He J. (2018). Regulatory Roles of Osteopontin in Production of Monocyte-Origin MCP-1. Cell Transplantation; 27(8): 1185–194.
23. Shikhpour E, Noorbakhsh P, Elnaz F, Farahnak S, Nasiri R and Neamatzadeh H. A. (2018). Survey on the role of interleukine 10 in breast cancer. Report of biochemistry and molecular biology; 7(1): 1-10.
24. Sundbaum J K. Eriksson N. Hallberg P. Lehto N. Wadelius M and Baecklund E. (2019). Methotrexate treatment in rheumatoid arthritis and elevated liver enzymes: A long‐term follow‐up of predictors, surveillance, and outcome in clinical practice. International journal of rheumatic disease; 22:1226–32.
25. Tan Z, Qian X, Jiang R, Liu Q, Wang Y, Chen C, Wang X, Ryffel and Sun B. (2013). IL 17 play acritical role in the pathogenesis of liver fibrosis through hepatic stellate cell activation. Immunology; 191:1-11.
26. Zhang L J and wang X Z. (2006). IL-10 and chronic liver disease. World journal of gastroenterology; 12:1681-85.
27. Zheng L, Chu J, Shi Y, Zhou X, Li Q, Cui L, Han Z, Han Y and Fan D. (2013). Bone marrow derived stem cells ameliorate hepatic fibrosis by down regulating interleukine-17. Cell and Bioscience;
3:1-9.
2. Abdelsalam S K, Hashim N T, Elsalamabi E M and Gismalla B G. (2011). Periodontal status of Rheumatoid arthritis patients in Khartoum state. Biomed central; 4:1-6.
3. Akdeniz S. Akdeniz O, Sakalli N, Gurer G, Ture M and Yesil H. (2018). The relationship between interleukin-17 and osteoporosis in patients with rheumatoid arthritis. Turk journal of osteoporos; 24: 46-52.
4. Al Zifzaf S D, Mokbel N A and Abdelaziz M D. (2015). interleukin-17 in Behcets disease: relation with clinical picture and disease activity. Egyptian rheumatology and rehabilitation; 42(2): 34-38.
5. Athanasiadous D, Jiang W, Goldbaum D, Saleem A, Basu K, Pacella S M, Böhm F C, Chromik R R, Hincke T M, Rodríguez N B A, Vali H, Wolf E S, Gray J J, Bui H K, Mckee D M. (2018). Nanostructure, osteopontin, and mechanical properties of calcitic avian eggshell. Science Advances; 4 (3219): 1-13.
6. Conway R and Carey J. (2017). Risk of liver disease in methotrexate treated patients. World J Hepatol; 9(26): 1092-1100.
7. Dinic R B, Rajkovic T S, Zivkovic V and Grgov S. (2018). Clinical connection between rheumatoid arthritis and liver damage. Rheumatology; 38:715-724.
8. Du W J, Zhen J H, Zeng Z Q, ZhengZ M, Xu Y, Qin L Y and Chen S J. (2013). Expressing of IL 17 associated with disease progression and liver fibrosis with hepatitis B virus infection: IL-17 in HBV infection. Diagnostic pathology; 8:1-7.
9. Elsedig M I, Elhag W, Elmak M J and Abbas M. (2014). Sero prevalence of human parvovirus B19 antibody among Sudanese patients with rheumatoid arthritis. American journal of ethno medicine; 1:402-407.
10. Elvira D, Nasrul E, Sofyan Y, Ecroli E D and Darwin E. (2018). Increased serum levels of interleukin-17 and transforming growth factor in patients with Graves’ disease. Earth and Environmental Science; 125: 1-4.
11. Holdsworth S R and Yi G P. (2015). Cytokines: Names and Numbers You Should Care About. Clinical Journal of the American Society of Nephrology; 10: 2243–54.
12. Iida T, Wagatsuma K, Hirayama D and Nakase H. (2018). Is Osteopontin a Friend or Foe of Cell Apoptosis in Inflammatory Gastrointestinal and Liver Diseases?. International Journal of Molecular Sciences; 19(7): 1-15.
13. Iwadate H, Kobayashi H, Kanno T, Asano T, Saito R, Sato S, Suzuki E, Watanabe H and Ohira H. (2013). Plasma Osteopontin is correlation with bone resorption marker in rheumatoid arthritis patients. International journal of rheumatic disease; 17(1).
14. Kobak S and Bes C. (2018). autumn late: geriatric rheumatoid arthritis. Therapeutic advances in musculoskeletal disease; 10(1) 3-11.
15. Kwan Ho T C, Mok CC, Cheung T T, Kwok Y K and Lung Yip M R. (2019). Management of rheumatoid arthritis. Clinical rheumatology; 38: 3331-50.
16. Luukkonen J, Pascual M L, Patlaka C, Lång P, Turunen S , Halleen J, Nousiainen T, Valkealahti M, Tuukkanen J, Andersson G R, Lehenkari P. (2017). Increased amount of phosphorylated proinflammatory osteopontin in rheumatoid arthritis synovia is associated to decreased tartrate-resistant acid phosphatase 5B/5A ratio. PLoS ONE; 12(8): 1-15.
17. Mengesha B G and Conti H R. (2017). The Role of IL-17 in Protection against Mucosal Candida Infections. Journal of Fungi; 3 (52): 1-12.
18. Mursal T, Elbager S , Fadl Elmola A, Ahmed R , Mohamed M, Abbas T. (2016). Differential diagnosis of anemia in rheumatoid arthritis Sudanese patients. World journal of pharmaceutical and medical research; 2(4): 1-4.
19. Negera E, Walker S, Bobosha K, Bekele Y, Endale B, Tarekegn A, Abebe M, Aseffa A, Dockrell H and Lockwood D N. (2018). The effect of prednisolone treatment on cytokine expression in patients with Erythema Nodosum Leprosum reaction. Frontiers immunology; 9: 1-15.
20. Noack M, Ndongo N and Miossec P. (2016). Evaluation of antiinflammatory effect of steroids and arthritis related biotherapies in an invitro coculture model with immune cells and synoviocytes. Frontiers in immunology; 7:1-10.
21. Rakuomi O, Go O, Kamau, Genga E, Okalebo F and Ogutu E. (2017). Prevalence of abnormal liver function tests in rheumatoid arthritis. African journal of rheumatology; 5(1): 70-75.
22. Shi L, Shi L, Wang X and He J. (2018). Regulatory Roles of Osteopontin in Production of Monocyte-Origin MCP-1. Cell Transplantation; 27(8): 1185–194.
23. Shikhpour E, Noorbakhsh P, Elnaz F, Farahnak S, Nasiri R and Neamatzadeh H. A. (2018). Survey on the role of interleukine 10 in breast cancer. Report of biochemistry and molecular biology; 7(1): 1-10.
24. Sundbaum J K. Eriksson N. Hallberg P. Lehto N. Wadelius M and Baecklund E. (2019). Methotrexate treatment in rheumatoid arthritis and elevated liver enzymes: A long‐term follow‐up of predictors, surveillance, and outcome in clinical practice. International journal of rheumatic disease; 22:1226–32.
25. Tan Z, Qian X, Jiang R, Liu Q, Wang Y, Chen C, Wang X, Ryffel and Sun B. (2013). IL 17 play acritical role in the pathogenesis of liver fibrosis through hepatic stellate cell activation. Immunology; 191:1-11.
26. Zhang L J and wang X Z. (2006). IL-10 and chronic liver disease. World journal of gastroenterology; 12:1681-85.
27. Zheng L, Chu J, Shi Y, Zhou X, Li Q, Cui L, Han Z, Han Y and Fan D. (2013). Bone marrow derived stem cells ameliorate hepatic fibrosis by down regulating interleukine-17. Cell and Bioscience;
3:1-9.
منشور
2020-09-15
القسم
Articles
