Anemia Evaluation of Serum Hepcidin Level in Sudanese Patients with Anemia of Chronic Renal Failure
Keywords:
Hepcidin, erythropoietic, Renal failure
Abstract
Anemia of chronic renal disease related to the failure of renal excretory functions, and to the renal endocrine function leads to an increased demand for red blood cells. As a consequence of the shortening of the red blood cells life span, failure of renal endocrine function leads to decreased erythorpoietic response because of impaired production of erythropoietin. Hepcidin is a major hormonal regulater of iron homeostasis Being synthesized in the liver, it inhibits iron release from macrophages. It could serve as an indicator of functional iron deficienc, in part, with renal failure
References
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3. CASANOVAS, G., MLECZKO-SANECKA, K., ALTAMURA, S., HENTZE, M. W. & MUCKENTHALER, M. U. 2009. Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD. J Mol Med (Berl), 87, 471-80.
4. KRYSIAK, R., KEDZIA, A., KRUPEJ-KEDZIERSKA, J., KOWALSKA, B. & OKOPIEN, B. 2015a. [Endocrine abnormalities in patients with chronic renal failure - part I]. Pol Merkur Lekarski, 38, 288-92.
5. KRYSIAK, R., KEDZIA, A., KRUPEJ-KEDZIERSKA, J., KOWALSKA, B. & OKOPIEN, B. 2015b. [Endocrine abnormalities in patients with chronic renal failure - part II]. Pol Merkur Lekarski, 38, 293-9.
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7.MCCRANOR, B. J., LANGDON, J. M., PRINCE, O. D., FEMNOU, L. K., BERGER, A. E., CHEADLE, C., CIVIN, C. I., KIM, A., RIVERA, S., GANZ, T., VAULONT, S., XUE, Q. L., WALSTON, J. D. & ROY, C. N. 2013. Investigation of the role of interleukin-6 and hepcidin antimicrobial peptide in the development of anemia with age. Haematologica, 98, 1633-40.
Published
2016-10-01
Section
Articles
