Bone Morphogenetic Protein (BMP15) Gene and its Relationship with Prolificacy in Sheep
(Review Paper)
Abstract
This review aims to study the Bone Morphogenetic Protein (BMP-15) gene and its association with ovulation rate and litter size in sheep. Fecundity traits such as ovulation rate and litter size are genetically regulated by many genes with small effects, and sometimes also by a single gene with major effects. BMP15 is essential for activation of the primordial follicle and subsequently in all stages of normal follicular development, maturation and ovulation. Mutations in the BMP-15 gene have been observed to be associated with increased ovulation rate and litter size in many sheep breeds worldwide.
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