Drugs use during pregnancy at Medani Maternity Hospital, Sudan

  • AbdElrahim D Haggaz Faculty of Medicine, University of Geizera, Medani, Sudan
  • Samah Ahmed Department of Obstetrics and Gynaecology, University of Khartoum, Khartoum, Sudan
  • Gasim I Gasim Medical College, Qassim University, Gassim, Saudi Arabia
  • Duria A Rayis Department of Obstetrics and Gynaecology, University of Khartoum, Khartoum, Sudan
  • Ishag Adam Department of Obstetrics and Gynaecology, University of Khartoum, Khartoum, Sudan

الملخص

Background: There is a limited knowledge on use of drugs during pregnancy including beneficial and possible adverse effects of drugs on both the mother and the fetus.
Objective: To investigate epidemiology of use of drugs during pregnancy.
Methods: A cross sectional hospital based study at Medani Hospital during the period December 2011. After signing an informed consent, a pre-tested questionnaire was used to gather data from each parturient mother on her age, parity, level of education, antenatal care visits and use of drug during the index pregnancy.
Results: The vast majority (334; 98.2%) of the interviewed women used drugs during the index pregnancy. Around ten percent (35; 10.5%) of these women used the drugs in the first trimester of pregnancy. The majority (266; 78.2%) used the drugs in third trimester and the rest used it in the second trimester. The most common drugs used were antibiotics, tonics, antimalarials and antiemetic.
Conclusion: There is a very high rate of drug use in this setting. Antibiotics and antimalarials drugs were the most used drugs.

المراجع

1. Andrade SE, Gurwitz JH, Davis RLet al. Prescription drug use in pregnancy.Am J Obstet Gynecol. 2004; 191(2):398-407.
2. Andrade SE, Raebel MA, Morse ANet al.Use of prescription medications with a potential for fetal harm among pregnant women.Pharmacoepidemiol Drug Saf. 2006; 15(8):546-54.
3. Cleary BJ, Butt H, Strawbridge JDet al. Medication use in early pregnancy-prevalence and determinants of use in a prospective cohort of women.Pharmacoepidemiol Drug Saf. 2010; 19(4):408-17.
4. Stephansson O, Granath F, Svensson Tet al. Drug use during pregnancy in Sweden - assessed by the Prescribed Drug Register and the Medical Birth Register.ClinEpidemiol. 2011;3: 43-50.
5. Adam I, Elhassan EM, Haggaz AEet al. Perspective of the epidemiology of malaria and anaemia and their impact on maternal and perinatal outcomes in Sudan.J Infect DevCtries. 2011;5(2):83-7
6. Adam I, Elwasila el T, Homeida MIs.Praziquantel therapy safe during pregnancy?Trans R Soc Trop Med Hyg. 2004; 98(9):540-3.
7. Adam I, Elwasila E, Mohammed Ali DAet al. Artemether in the treatment of falciparum malaria during pregnancy in eastern Sudan.Trans R Soc Trop Med Hyg. 2004; 98(9):509-13.
8. Adam I, Elhassan EM, Omer EMet al. Safety of artemisinins during early pregnancy, assessed in 62 Sudanese women.Ann Trop Med Parasitol. 2009; 103(3):205-10.
9. Sevene E, Bardají A, Mariano Aet al.Drug exposure and pregnancy outcome in Mozambique.Paediatr Drugs. 2012;14(1):43-9.
10. Eze UI, Eferakeya AE, Oparah AC. Assessment of prescription profile of pregnant women visiting antenatal clinics. Pharm Pract 2007; 5 Suppl. 3: 135-9.
11. Hamdan HZ, Ziad AH, Ali SKet al.Epidemiology of urinary tract infections and antibiotics sensitivity among pregnant women at Khartoum North Hospital.AnnClinMicrobiolAntimicrob. 2011;10:2.
12. McGready R, White NJ, Nosten F.Parasitological efficacy of antimalarials in the treatment and prevention of falciparum malaria in pregnancy 1998 to 2009: a systematic review.BJOG. 2011;118(2):123-
13. Källén BA. Methodological issues in the epidemiological study of the teratogenicity of drugs. CongenitAnom (Kyoto) 2005; 45(2):44–51.
14. Mitchell AA. In: Special considerations in studies of drug-induced birth defects. Pharmacoepidemiology.3rd ed. Strom BL, editor.Chichester (UK): John Wiley & Sons; 2002. pp. 749–763.
15. Meidahl Petersen K, Jimenez-Solem E, Andersen JTet al. b-Blocker treatment during pregnancy and adverse pregnancy outcomes: a nationwide population-based cohort study. BMJ Open. 2012;2 (4).
16. Källén BA, OtterbladOlausson P, Danielsson BR. Is erythromycin therapy teratogenic in humans? ReprodToxicol. 2005; 20(2):209–214.Amann U, Egen-Lappe V, Strunz-LehnerCet al. Antibiotics in pregnancy: analysis of potential risks and determinants in a large German statutory sickness fund population. Pharmacoepidemiol Drug Saf. 2006; 15 (5):327–337.
17. Van Marter LJ, Hernandez-Diaz S, Werler MMet al. Nonsteroidalantiinflammatory drugs in late pregnancy and persistent pulmonary hypertension of the newborn Pediatrics. 2013;131(1):79-87.
18. Andersen AB, Farkas DK, Mehnert Fet al. Use of prescription paracetamol during pregnancy and risk of asthma in children: a population-based Danish cohort study.Clin Epidemiol.2012;4:33-40.
منشور
2021-08-13
القسم
Original Articles